Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review
Shuwan Xu,1,2,* Cong Xu,1,* Jiahua Xu,1 Kun Zhang,2 Huanji Zhang1 1Cardiovascular Department, the Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, Guangdong, People’s Republic of China; 2Department of Cardiology, Sun Yat-Sen Memorial Hospital of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-12-01
|
| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/macrophage-heterogeneity-and-its-impact-on-myocardial-ischemia-reperfu-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797401147368013824 |
|---|---|
| author | Xu S Xu C Xu J Zhang K Zhang H |
| author_facet | Xu S Xu C Xu J Zhang K Zhang H |
| author_sort | Xu S |
| collection | DOAJ |
| description | Shuwan Xu,1,2,* Cong Xu,1,* Jiahua Xu,1 Kun Zhang,2 Huanji Zhang1 1Cardiovascular Department, the Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, Guangdong, People’s Republic of China; 2Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huanji Zhang, Cardiovascular Department, The Eighth Affiliated Hospital of Sun Yat-Sen University, No. 3025 Shennan Middle Road, Shenzhen, 518033, People’s Republic of China, Tel +8613688808979, Email zhanghj65@mail.sysu.edu.cn Kun Zhang, Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, People’s Republic of China, Tel +8613450390268, Email zszhangk@hotmail.comAbstract: The coronary reperfusion following acute myocardial infarction can paradoxically trigger myocardial ischemia-reperfusion (IR) injury. This complex phenomenon involves the intricate interplay of different subsets of macrophages. These macrophages are crucial players in the post-infarction inflammatory response and subsequent myocardial anti-inflammatory repair. However, their diverse functions can lead to both beneficial and detrimental effects. On one hand, these macrophages play a crucial role in orchestrating the inflammatory response, aiding in the clearance of cellular debris and initiating tissue repair mechanisms. On the other hand, their excessive infiltration and activation can contribute to the perpetuation of the inflammatory cascade, leading to additional myocardial injury and adverse cardiac remodeling. Multiple mechanisms contribute to the IR injury mediated by macrophages, including oxidative stress, apoptosis, and autophagy. These processes further exacerbate the damage to the already vulnerable myocardial tissue. To address this delicate balance, therapeutic strategies aiming to target and modulate macrophage polarization and function are being explored. By fine-tuning the immune inflammatory response, such interventions hold promise in mitigating post-infarction myocardial injury and fostering a more favorable environment for myocardial healing and recovery. Through advancements in this area of research, potential anti-inflammatory interventions may pave the way for improved clinical outcomes and better management of patients after acute myocardial infarction.Keywords: ischemia-reperfusion injury, macrophages, inflammatory cascade, cardiac remodeling, oxidative stress |
| first_indexed | 2024-03-09T02:05:41Z |
| format | Article |
| id | doaj.art-6696a74c58a648ffb18b041f2e3767bb |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-09T02:05:41Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-6696a74c58a648ffb18b041f2e3767bb2023-12-07T18:03:42ZengDove Medical PressJournal of Inflammation Research1178-70312023-12-01Volume 165971598788855Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative ReviewXu SXu CXu JZhang KZhang HShuwan Xu,1,2,* Cong Xu,1,* Jiahua Xu,1 Kun Zhang,2 Huanji Zhang1 1Cardiovascular Department, the Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, Guangdong, People’s Republic of China; 2Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huanji Zhang, Cardiovascular Department, The Eighth Affiliated Hospital of Sun Yat-Sen University, No. 3025 Shennan Middle Road, Shenzhen, 518033, People’s Republic of China, Tel +8613688808979, Email zhanghj65@mail.sysu.edu.cn Kun Zhang, Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, People’s Republic of China, Tel +8613450390268, Email zszhangk@hotmail.comAbstract: The coronary reperfusion following acute myocardial infarction can paradoxically trigger myocardial ischemia-reperfusion (IR) injury. This complex phenomenon involves the intricate interplay of different subsets of macrophages. These macrophages are crucial players in the post-infarction inflammatory response and subsequent myocardial anti-inflammatory repair. However, their diverse functions can lead to both beneficial and detrimental effects. On one hand, these macrophages play a crucial role in orchestrating the inflammatory response, aiding in the clearance of cellular debris and initiating tissue repair mechanisms. On the other hand, their excessive infiltration and activation can contribute to the perpetuation of the inflammatory cascade, leading to additional myocardial injury and adverse cardiac remodeling. Multiple mechanisms contribute to the IR injury mediated by macrophages, including oxidative stress, apoptosis, and autophagy. These processes further exacerbate the damage to the already vulnerable myocardial tissue. To address this delicate balance, therapeutic strategies aiming to target and modulate macrophage polarization and function are being explored. By fine-tuning the immune inflammatory response, such interventions hold promise in mitigating post-infarction myocardial injury and fostering a more favorable environment for myocardial healing and recovery. Through advancements in this area of research, potential anti-inflammatory interventions may pave the way for improved clinical outcomes and better management of patients after acute myocardial infarction.Keywords: ischemia-reperfusion injury, macrophages, inflammatory cascade, cardiac remodeling, oxidative stresshttps://www.dovepress.com/macrophage-heterogeneity-and-its-impact-on-myocardial-ischemia-reperfu-peer-reviewed-fulltext-article-JIRischemia-reperfusion injurymacrophagesinflammatory cascadecardiac remodelingoxidative stress |
| spellingShingle | Xu S Xu C Xu J Zhang K Zhang H Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review Journal of Inflammation Research ischemia-reperfusion injury macrophages inflammatory cascade cardiac remodeling oxidative stress |
| title | Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review |
| title_full | Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review |
| title_fullStr | Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review |
| title_full_unstemmed | Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review |
| title_short | Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review |
| title_sort | macrophage heterogeneity and its impact on myocardial ischemia reperfusion injury an integrative review |
| topic | ischemia-reperfusion injury macrophages inflammatory cascade cardiac remodeling oxidative stress |
| url | https://www.dovepress.com/macrophage-heterogeneity-and-its-impact-on-myocardial-ischemia-reperfu-peer-reviewed-fulltext-article-JIR |
| work_keys_str_mv | AT xus macrophageheterogeneityanditsimpactonmyocardialischemiareperfusioninjuryanintegrativereview AT xuc macrophageheterogeneityanditsimpactonmyocardialischemiareperfusioninjuryanintegrativereview AT xuj macrophageheterogeneityanditsimpactonmyocardialischemiareperfusioninjuryanintegrativereview AT zhangk macrophageheterogeneityanditsimpactonmyocardialischemiareperfusioninjuryanintegrativereview AT zhangh macrophageheterogeneityanditsimpactonmyocardialischemiareperfusioninjuryanintegrativereview |