Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule
Background: Retinoblastomas account for 4% of malignancies in children, 1-2% of which are diffuse infiltrating retinoblastomas. Diffuse anterior retinoblastoma is rare and does not involve the retina. Here, we report on a diffuse anterior retinoblastoma with large sarcoidosis-like nodules on the iri...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2015-12-01
|
| Series: | Case Reports in Ophthalmology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/442744 |
| _version_ | 1811195739715403776 |
|---|---|
| author | Koji Kitazawa Kenji Nagata Yukito Yamanaka Yasumichi Kuwahara Tomoko Iehara Shigeru Kinoshita Chie Sotozono |
| author_facet | Koji Kitazawa Kenji Nagata Yukito Yamanaka Yasumichi Kuwahara Tomoko Iehara Shigeru Kinoshita Chie Sotozono |
| author_sort | Koji Kitazawa |
| collection | DOAJ |
| description | Background: Retinoblastomas account for 4% of malignancies in children, 1-2% of which are diffuse infiltrating retinoblastomas. Diffuse anterior retinoblastoma is rare and does not involve the retina. Here, we report on a diffuse anterior retinoblastoma with large sarcoidosis-like nodules on the iris that were responsive to anti-inflammatory therapy. Case: We present a 6-year-old girl who had anterior uveitis with white nodules on the iris and posterior surface of the cornea in her right eye. The nodules initially responded well to anti-inflammatory treatment. However, anterior segment optical coherence tomography (AS-OCT) showed that the nodules gradually grew, shrinking the iris. We then collected the aqueous humor for diagnosis. A biopsy revealed clusters of small cells with a high nuclear-to-cytoplasm ratio with partial rosette formation. Therefore, we diagnosed diffuse anterior retinoblastoma without retinal involvement and performed enucleation of the right eye. The histopathology demonstrated undifferentiated cells similar to those seen on the biopsy, and tumor cells invaded the iris stroma, posterior surface of the cornea, ciliary body, and sclera. After the enucleation, she underwent chemotherapy and remains alive. Conclusion: A differential diagnosis of retinoblastoma should be considered when white nodules refractory to anti-inflammatory therapy occur in the eye, even in the absence of obvious retinal masses. AS-OCT findings are useful in assessing retinoblastoma. |
| first_indexed | 2024-04-12T00:48:08Z |
| format | Article |
| id | doaj.art-66972db12c214d8cad492f0eebe29a1b |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-04-12T00:48:08Z |
| publishDate | 2015-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-66972db12c214d8cad492f0eebe29a1b2022-12-22T03:54:48ZengKarger PublishersCase Reports in Ophthalmology1663-26992015-12-016344344710.1159/000442744442744Diffuse Anterior Retinoblastoma with Sarcoidosis-Like NoduleKoji KitazawaKenji NagataYukito YamanakaYasumichi KuwaharaTomoko IeharaShigeru KinoshitaChie SotozonoBackground: Retinoblastomas account for 4% of malignancies in children, 1-2% of which are diffuse infiltrating retinoblastomas. Diffuse anterior retinoblastoma is rare and does not involve the retina. Here, we report on a diffuse anterior retinoblastoma with large sarcoidosis-like nodules on the iris that were responsive to anti-inflammatory therapy. Case: We present a 6-year-old girl who had anterior uveitis with white nodules on the iris and posterior surface of the cornea in her right eye. The nodules initially responded well to anti-inflammatory treatment. However, anterior segment optical coherence tomography (AS-OCT) showed that the nodules gradually grew, shrinking the iris. We then collected the aqueous humor for diagnosis. A biopsy revealed clusters of small cells with a high nuclear-to-cytoplasm ratio with partial rosette formation. Therefore, we diagnosed diffuse anterior retinoblastoma without retinal involvement and performed enucleation of the right eye. The histopathology demonstrated undifferentiated cells similar to those seen on the biopsy, and tumor cells invaded the iris stroma, posterior surface of the cornea, ciliary body, and sclera. After the enucleation, she underwent chemotherapy and remains alive. Conclusion: A differential diagnosis of retinoblastoma should be considered when white nodules refractory to anti-inflammatory therapy occur in the eye, even in the absence of obvious retinal masses. AS-OCT findings are useful in assessing retinoblastoma.http://www.karger.com/Article/FullText/442744ChemotherapySarcoidosisDiffuse infiltrating retinoblastomaAnterior segment optical coherence tomographyEnucleationRetinoblastomaDiffuse anterior retinoblastoma |
| spellingShingle | Koji Kitazawa Kenji Nagata Yukito Yamanaka Yasumichi Kuwahara Tomoko Iehara Shigeru Kinoshita Chie Sotozono Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule Case Reports in Ophthalmology Chemotherapy Sarcoidosis Diffuse infiltrating retinoblastoma Anterior segment optical coherence tomography Enucleation Retinoblastoma Diffuse anterior retinoblastoma |
| title | Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule |
| title_full | Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule |
| title_fullStr | Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule |
| title_full_unstemmed | Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule |
| title_short | Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule |
| title_sort | diffuse anterior retinoblastoma with sarcoidosis like nodule |
| topic | Chemotherapy Sarcoidosis Diffuse infiltrating retinoblastoma Anterior segment optical coherence tomography Enucleation Retinoblastoma Diffuse anterior retinoblastoma |
| url | http://www.karger.com/Article/FullText/442744 |
| work_keys_str_mv | AT kojikitazawa diffuseanteriorretinoblastomawithsarcoidosislikenodule AT kenjinagata diffuseanteriorretinoblastomawithsarcoidosislikenodule AT yukitoyamanaka diffuseanteriorretinoblastomawithsarcoidosislikenodule AT yasumichikuwahara diffuseanteriorretinoblastomawithsarcoidosislikenodule AT tomokoiehara diffuseanteriorretinoblastomawithsarcoidosislikenodule AT shigerukinoshita diffuseanteriorretinoblastomawithsarcoidosislikenodule AT chiesotozono diffuseanteriorretinoblastomawithsarcoidosislikenodule |