Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities.
OBJECTIVES:This article focuses on the differences between CT findings of HIV-negative patients who have cavities with nontuberculous mycobacteria (NTM) disease and those with Mycobacterium tuberculosis infections (TB). METHODS:We retrospectively reviewed 128 NTM disease patients (79 males and 49 fe...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5367717?pdf=render |
| _version_ | 1818161325224755200 |
|---|---|
| author | Cherry Kim So Hee Park Sang Young Oh Sung-Soo Kim Kyung-Wook Jo Tae Sun Shim Mi Young Kim |
| author_facet | Cherry Kim So Hee Park Sang Young Oh Sung-Soo Kim Kyung-Wook Jo Tae Sun Shim Mi Young Kim |
| author_sort | Cherry Kim |
| collection | DOAJ |
| description | OBJECTIVES:This article focuses on the differences between CT findings of HIV-negative patients who have cavities with nontuberculous mycobacteria (NTM) disease and those with Mycobacterium tuberculosis infections (TB). METHODS:We retrospectively reviewed 128 NTM disease patients (79 males and 49 females) with cavities in chest CT, matched for age and gender with 128 TB patients in the same period. Sputum cultures of all patients were positive for pathogens. Two independent chest radiologists evaluated the characteristics of the largest cavity and related factors. RESULTS:Interobserver agreement was excellent (κ value, 0.853-0.938). Cavity walls in NTM disease were significantly thinner (6.9±4 mm vs 10.9±6 mm, P<0.001) and more even (the ratio of thickness, 2.6±1 vs 3.7±2, P<0.001) than those in TB. The thickening of adjacent pleura next to the cavity was also significantly thicker in NTM than TB (P<0.001). However, in the multivariate analysis, thickening of adjacent pleura was the only significant factor among the representative cavity findings (Odds ratio [OR], 6.49; P<0.001). In addition, ill-defined tree-in-bud nodules (OR, 8.82; P<0.001), number of non-cavitary nodules (≥10mm) (OR, 0.72; P = 0.003), and bronchiectasis in the RUL (OR, 5.3; P = 0.002) were significantly associated ancillary findings with NTM disease in the multivariate analysis. CONCLUSIONS:The major cavities in NTM disease generally have thinner and more even walls than those in TB. When cavities are associated with adjacent pleural thickening, ill-defined satellite tree-in-bud nodules, or fewer non-cavitary nodules ≥10 mm, these CT findings are highly suggestive of NTM disease rather than TB. |
| first_indexed | 2024-12-11T16:15:58Z |
| format | Article |
| id | doaj.art-66974e8496284a02ba58d3ce73bbb5fd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T16:15:58Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-66974e8496284a02ba58d3ce73bbb5fd2022-12-22T00:58:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017424010.1371/journal.pone.0174240Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities.Cherry KimSo Hee ParkSang Young OhSung-Soo KimKyung-Wook JoTae Sun ShimMi Young KimOBJECTIVES:This article focuses on the differences between CT findings of HIV-negative patients who have cavities with nontuberculous mycobacteria (NTM) disease and those with Mycobacterium tuberculosis infections (TB). METHODS:We retrospectively reviewed 128 NTM disease patients (79 males and 49 females) with cavities in chest CT, matched for age and gender with 128 TB patients in the same period. Sputum cultures of all patients were positive for pathogens. Two independent chest radiologists evaluated the characteristics of the largest cavity and related factors. RESULTS:Interobserver agreement was excellent (κ value, 0.853-0.938). Cavity walls in NTM disease were significantly thinner (6.9±4 mm vs 10.9±6 mm, P<0.001) and more even (the ratio of thickness, 2.6±1 vs 3.7±2, P<0.001) than those in TB. The thickening of adjacent pleura next to the cavity was also significantly thicker in NTM than TB (P<0.001). However, in the multivariate analysis, thickening of adjacent pleura was the only significant factor among the representative cavity findings (Odds ratio [OR], 6.49; P<0.001). In addition, ill-defined tree-in-bud nodules (OR, 8.82; P<0.001), number of non-cavitary nodules (≥10mm) (OR, 0.72; P = 0.003), and bronchiectasis in the RUL (OR, 5.3; P = 0.002) were significantly associated ancillary findings with NTM disease in the multivariate analysis. CONCLUSIONS:The major cavities in NTM disease generally have thinner and more even walls than those in TB. When cavities are associated with adjacent pleural thickening, ill-defined satellite tree-in-bud nodules, or fewer non-cavitary nodules ≥10 mm, these CT findings are highly suggestive of NTM disease rather than TB.http://europepmc.org/articles/PMC5367717?pdf=render |
| spellingShingle | Cherry Kim So Hee Park Sang Young Oh Sung-Soo Kim Kyung-Wook Jo Tae Sun Shim Mi Young Kim Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities. PLoS ONE |
| title | Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities. |
| title_full | Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities. |
| title_fullStr | Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities. |
| title_full_unstemmed | Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities. |
| title_short | Comparison of chest CT findings in nontuberculous mycobacterial diseases vs. Mycobacterium tuberculosis lung disease in HIV-negative patients with cavities. |
| title_sort | comparison of chest ct findings in nontuberculous mycobacterial diseases vs mycobacterium tuberculosis lung disease in hiv negative patients with cavities |
| url | http://europepmc.org/articles/PMC5367717?pdf=render |
| work_keys_str_mv | AT cherrykim comparisonofchestctfindingsinnontuberculousmycobacterialdiseasesvsmycobacteriumtuberculosislungdiseaseinhivnegativepatientswithcavities AT soheepark comparisonofchestctfindingsinnontuberculousmycobacterialdiseasesvsmycobacteriumtuberculosislungdiseaseinhivnegativepatientswithcavities AT sangyoungoh comparisonofchestctfindingsinnontuberculousmycobacterialdiseasesvsmycobacteriumtuberculosislungdiseaseinhivnegativepatientswithcavities AT sungsookim comparisonofchestctfindingsinnontuberculousmycobacterialdiseasesvsmycobacteriumtuberculosislungdiseaseinhivnegativepatientswithcavities AT kyungwookjo comparisonofchestctfindingsinnontuberculousmycobacterialdiseasesvsmycobacteriumtuberculosislungdiseaseinhivnegativepatientswithcavities AT taesunshim comparisonofchestctfindingsinnontuberculousmycobacterialdiseasesvsmycobacteriumtuberculosislungdiseaseinhivnegativepatientswithcavities AT miyoungkim comparisonofchestctfindingsinnontuberculousmycobacterialdiseasesvsmycobacteriumtuberculosislungdiseaseinhivnegativepatientswithcavities |