Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function

Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function

KV1.5 channels are key players in the regulation of vascular tone and atrial excitability and their impairment is associated with cardiovascular diseases including pulmonary arterial hypertension (PAH) and atrial fibrillation (AF). Unfortunately, pharmacological strategies to improve KV1.5 channel f...

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Bibliographic Details
Main Authors: Alba Vera-Zambrano, Maria Baena-Nuevo, Susanne Rinné, Marta Villegas-Esguevillas, Bianca Barreira, Gokcen Telli, Angela de Benito-Bueno, José Antonio Blázquez, Belén Climent, Francisco Pérez-Vizcaino, Carmen Valenzuela, Niels Decher, Teresa Gonzalez, Angel Cogolludo
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Pharmacological Research
Subjects:
KV1.5 channels
Sigma-1 receptor
Pulmonary arterial hypertension
S1R agonists
Potassium channel modulation
Atrial fibrillation
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823000403

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