Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus
PurposeThis study investigated the prevalence of islet autoantibodies in children and adults with T1DM according to their age and the duration of disease.MethodsWe measured the levels of islet autoantibodies, including antiglutamic acid decarboxylase antibody (anti-GAD Ab), and combined these with a...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2013-06-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-18-65.pdf |
| _version_ | 1818309323406704640 |
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| author | Young Hwa Kong Min Sun Kim Dae-Yeol Lee |
| author_facet | Young Hwa Kong Min Sun Kim Dae-Yeol Lee |
| author_sort | Young Hwa Kong |
| collection | DOAJ |
| description | PurposeThis study investigated the prevalence of islet autoantibodies in children and adults with T1DM according to their age and the duration of disease.MethodsWe measured the levels of islet autoantibodies, including antiglutamic acid decarboxylase antibody (anti-GAD Ab), and combined these with anthropometric measurements and laboratory tests of 137 patients newly diagnosed with T1DM during the last 20 years. The subjects were subdivided into four groups according to their age at the onset of the disease. We then compared the prevalence of islet autoantibodies in the different age groups with the duration of disease.ResultsAmong the 137 patients, 68.9% tested positive for islet autoantibodies (71.4% within 1 year; 67.7% after 1 year of the disease onset). Within 1 year of the onset of the disease, 66.3% of the patients were positive for the anti-GAD Ab, and 35.6% were positive for IAAs. The prevalence of islet autoantibodies was significantly higher in the prepubertal groups than in the postpubertal groups (80.0% vs. 58.3%). The rate of positive islet autoantibodies changed with the duration of disease, and it differed according to the type of autoantibody and the age of the patient.ConclusionThe rates of positive islet autoantibodies were significantly higher in younger than in older patients at the time of the diagnosis of the disease. The positive rates were significantly changed 1 year after the onset of the disease in the preschool and the children groups. So these findings suggest that we need to diagnose type 1B diabetes distinguished T2DM in aldolescent group, carefully. |
| first_indexed | 2024-12-13T07:28:20Z |
| format | Article |
| id | doaj.art-669d40b7a6734826aded6f51b381e685 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-13T07:28:20Z |
| publishDate | 2013-06-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-669d40b7a6734826aded6f51b381e6852022-12-21T23:55:16ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922013-06-01182657010.6065/apem.2013.18.2.65526Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitusYoung Hwa Kong0Min Sun Kim1Dae-Yeol Lee2Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.PurposeThis study investigated the prevalence of islet autoantibodies in children and adults with T1DM according to their age and the duration of disease.MethodsWe measured the levels of islet autoantibodies, including antiglutamic acid decarboxylase antibody (anti-GAD Ab), and combined these with anthropometric measurements and laboratory tests of 137 patients newly diagnosed with T1DM during the last 20 years. The subjects were subdivided into four groups according to their age at the onset of the disease. We then compared the prevalence of islet autoantibodies in the different age groups with the duration of disease.ResultsAmong the 137 patients, 68.9% tested positive for islet autoantibodies (71.4% within 1 year; 67.7% after 1 year of the disease onset). Within 1 year of the onset of the disease, 66.3% of the patients were positive for the anti-GAD Ab, and 35.6% were positive for IAAs. The prevalence of islet autoantibodies was significantly higher in the prepubertal groups than in the postpubertal groups (80.0% vs. 58.3%). The rate of positive islet autoantibodies changed with the duration of disease, and it differed according to the type of autoantibody and the age of the patient.ConclusionThe rates of positive islet autoantibodies were significantly higher in younger than in older patients at the time of the diagnosis of the disease. The positive rates were significantly changed 1 year after the onset of the disease in the preschool and the children groups. So these findings suggest that we need to diagnose type 1B diabetes distinguished T2DM in aldolescent group, carefully.http://e-apem.org/upload/pdf/apem-18-65.pdfIslet autoantibodyType 1 diabetes mellitusGlutamic acid decarboxylaseInsulin autoantibody |
| spellingShingle | Young Hwa Kong Min Sun Kim Dae-Yeol Lee Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus Annals of Pediatric Endocrinology & Metabolism Islet autoantibody Type 1 diabetes mellitus Glutamic acid decarboxylase Insulin autoantibody |
| title | Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus |
| title_full | Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus |
| title_fullStr | Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus |
| title_full_unstemmed | Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus |
| title_short | Comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus |
| title_sort | comparison of the prevalence of islet autoantibodies according to age and disease duration in patients with type 1 diabetes mellitus |
| topic | Islet autoantibody Type 1 diabetes mellitus Glutamic acid decarboxylase Insulin autoantibody |
| url | http://e-apem.org/upload/pdf/apem-18-65.pdf |
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