Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers

Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers

Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specifi c PCR. Chromosome damage in peripheral...

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Bibliographic Details
Main Authors: Fen Wu, Jing Liu, Yu-Lan Qiu, Wei Wang, Shou-Min Zhu, Pin Sun, Wen-Bin Miao, Yong-Liang Li, Paul W. Brandt-Rauf, Zhao-Lin Xia
Format: Article
Language:English
Published: Nofer Institute of Occupational Medicine 2013-02-01
Series:International Journal of Occupational Medicine and Environmental Health
Subjects:
vinyl chloride monomer
chromosome damage
MGMT
hMLH1
DNA methylation
Online Access:http://ijomeh.eu/Correlation-of-chromosome-damage-and-promoter-methylation-status-of-the-dna-repair-genes-mgmt-and-hmlh1-in-chinese-vinyl-chloride-monomer-vcm-exposed-workers,2225,0,2.html

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