Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer
TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage. In this study, the expression levels of epidermal growth factor receptor (EGFR) and cyclin D1 were assesse...
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MDPI AG
2022-03-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/3/93 |
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| author | Se-Il Go Gyung Hyuck Ko Won Sup Lee Jeong-Hee Lee Sang-Ho Jeong Young-Joon Lee Soon Chan Hong Woo Song Ha |
| author_facet | Se-Il Go Gyung Hyuck Ko Won Sup Lee Jeong-Hee Lee Sang-Ho Jeong Young-Joon Lee Soon Chan Hong Woo Song Ha |
| author_sort | Se-Il Go |
| collection | DOAJ |
| description | TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage. In this study, the expression levels of epidermal growth factor receptor (EGFR) and cyclin D1 were assessed in 96 tissue samples, including non-tumorous tissue, adenoma, and carcinoma. Then, the prognostic impact of EGFR and cyclin D1 was retrospectively investigated in 316 patients who underwent R0 resection for GC. EGFR positivity increased as gastric tissue became malignant, and cyclin D1 positivity was increased in all the tumorous tissues. However, there was no survival difference caused by the EGFR positivity, while the cyclin D1-postive group had worse overall survival (OS) than the cyclin D1-negative group in stage I GC (10-year survival rate (10-YSR): 62.8% vs. 86.5%, <i>p</i> = 0.010). In subgroup analyses for the propensity score-matched (PSM) cohort, there were also significant differences in the OS according to the cyclin D1 positivity in stage I GC but not in stage II and III GC. Upon multivariate analysis, cyclin D1 positivity was an independent prognostic factor in stage I GC. In conclusion, cyclin D1 may be a useful biomarker for predicting prognosis in stage I GC. |
| first_indexed | 2024-03-09T19:58:57Z |
| format | Article |
| id | doaj.art-66a1ab6d6bca4b8193f1fcda6b1dcf5c |
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| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T19:58:57Z |
| publishDate | 2022-03-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj.art-66a1ab6d6bca4b8193f1fcda6b1dcf5c2023-11-24T00:48:35ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-03-014431395140610.3390/cimb44030093Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric CancerSe-Il Go0Gyung Hyuck Ko1Won Sup Lee2Jeong-Hee Lee3Sang-Ho Jeong4Young-Joon Lee5Soon Chan Hong6Woo Song Ha7Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Institute of Health Sciences, Gyeongsang National University College of Medicine, Changwon 51472, KoreaDepartment of Pathology, Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, KoreaDepartment of Internal Medicine, Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, KoreaDepartment of Pathology, Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, KoreaDepartment of Surgery, Gyeongsang National University Changwon Hospital, Institute of Health Sciences, Gyeongsang National University College of Medicine, Changwon 51472, KoreaDepartment of Surgery, Gyeongsang National University Changwon Hospital, Institute of Health Sciences, Gyeongsang National University College of Medicine, Changwon 51472, KoreaDepartment of Surgery, Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, KoreaDepartment of Surgery, Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, KoreaTNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage. In this study, the expression levels of epidermal growth factor receptor (EGFR) and cyclin D1 were assessed in 96 tissue samples, including non-tumorous tissue, adenoma, and carcinoma. Then, the prognostic impact of EGFR and cyclin D1 was retrospectively investigated in 316 patients who underwent R0 resection for GC. EGFR positivity increased as gastric tissue became malignant, and cyclin D1 positivity was increased in all the tumorous tissues. However, there was no survival difference caused by the EGFR positivity, while the cyclin D1-postive group had worse overall survival (OS) than the cyclin D1-negative group in stage I GC (10-year survival rate (10-YSR): 62.8% vs. 86.5%, <i>p</i> = 0.010). In subgroup analyses for the propensity score-matched (PSM) cohort, there were also significant differences in the OS according to the cyclin D1 positivity in stage I GC but not in stage II and III GC. Upon multivariate analysis, cyclin D1 positivity was an independent prognostic factor in stage I GC. In conclusion, cyclin D1 may be a useful biomarker for predicting prognosis in stage I GC.https://www.mdpi.com/1467-3045/44/3/93cyclin D1epidermal growth factor receptor (EGFR)stage I gastric cancerearly gastric cancernode-negative gastric cancer |
| spellingShingle | Se-Il Go Gyung Hyuck Ko Won Sup Lee Jeong-Hee Lee Sang-Ho Jeong Young-Joon Lee Soon Chan Hong Woo Song Ha Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer Current Issues in Molecular Biology cyclin D1 epidermal growth factor receptor (EGFR) stage I gastric cancer early gastric cancer node-negative gastric cancer |
| title | Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer |
| title_full | Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer |
| title_fullStr | Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer |
| title_full_unstemmed | Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer |
| title_short | Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer |
| title_sort | cyclin d1 serves as a poor prognostic biomarker in stage i gastric cancer |
| topic | cyclin D1 epidermal growth factor receptor (EGFR) stage I gastric cancer early gastric cancer node-negative gastric cancer |
| url | https://www.mdpi.com/1467-3045/44/3/93 |
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