Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer’s disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core of the γ-secretase complex...

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Bibliographic Details
Main Authors: Mercedes A Hernandez-Sapiens, Edwin E Reza-Zaldívar, Ana L Márquez-Aguirre, Ulises Gómez-Pinedo, Jorge Matias-Guiu, Ricardo R Cevallos, Juan C Mateos-Díaz, Víctor J Sánchez-González, Alejandro A Canales-Aguirre
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
familial alzheimer’s disease; familial alzheimer’s disease-induced pluripotent stem cells models; induced pluripotent stem cells; neurogenesis; neuronal differentiation; notch; presenilin 1; psen1 mutations; γ-secretase complex
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=31;epage=37;aulast=Hernandez-Sapiens

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