Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patients
Objective: to study clinical presentation, course variants and complications of Takayasu arteritis (AT) in Kyrgyz patients.Patients and methods. 75 Kyrgyz patients with a definite diagnosis of AT were included in the study, most of them were women (93.3%). The median age was 33 [23; 40] years, the m...
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2021-02-01
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| author | G. M. Koilubaeva E. R. Karimova S. K. Solovyev E. A. Aseeva F. S. Dzhuzenova E. L. Nasonov E. Zh. Dzhishambaev D. A. Usupbaeva A. K. Turusbekova |
| author_facet | G. M. Koilubaeva E. R. Karimova S. K. Solovyev E. A. Aseeva F. S. Dzhuzenova E. L. Nasonov E. Zh. Dzhishambaev D. A. Usupbaeva A. K. Turusbekova |
| author_sort | G. M. Koilubaeva |
| collection | DOAJ |
| description | Objective: to study clinical presentation, course variants and complications of Takayasu arteritis (AT) in Kyrgyz patients.Patients and methods. 75 Kyrgyz patients with a definite diagnosis of AT were included in the study, most of them were women (93.3%). The median age was 33 [23; 40] years, the median duration of the disease was 7 [3.0; 13.0] years. The anatomical type of vascular lesions was determined using the angiographic classification of R. Moriwaki et al., the AT activity – according to the BVAS index, the clinical stage of AT – using the R. Jefferson classification, the severity and prognosis of the disease – according to the K. Ishikawa classification. Highly sensitivity CRP (hsCRP) was assessed in 44 (58.67%) patients, interleukin 6 (IL6) – in 26 (34.7%). Instrumental procedures included duplex Doppler ultrasonography of peripheral arteries and contrast-enhanced computed pan aortography.Results and discussion. The mean age of AT onset was 24.4±9.4 years. The majority of patients had V anatomical type of vascular lesions (61.3%), vascular stage (89.3%), severe stenosis (54.7%) with predominant affection of the brachiocephalic trunk (68%), common carotid arteries (53.7 %) and renal (52%) arteries. Most patients (82.7%) at the time of inclusion in the study had a severe exacerbation of AT according to the BVAS index. An increase in hsCRP level was seen in 66% of cases, IL6 – in 31%. At the onset of AT, 20% of patients had fever, general weakness, weight loss, myalgia and/or arthralgia. 43% of patients had ≥2 complications. The clinical manifestations of AT were mainly characterized by cardiovascular pathology (77.3%) with the formation of relative aortic valve insufficiency (AVI) (93.1%) and kidney damage (57.3%) with the development of renovascular arterial hypertension (91%). At the first visit, more than one third of patients (37.3%) had irreversible damage, accompanied in half of them by AVI degree II or III.Conclusion. Young women predominated among Kyrgyz patients with AT. Most of the patients had anatomical type V AT (61.3%), vascular stage (89.3%), severe stenosis (54.7%), affection of the brachiocephalic trunk (68%), common carotid (57.3%) and renal (52%) arteries. Severe exacerbation of the disease was observed in 82.7% of patients. The presence of ≥2 complications worsened the prognosis of AT. The clinical manifestations of AT were characterized mainly by cardiovascular pathology (77.3%) and kidney damage (57.3%). In more than one third of patients (37.3%) AT was diagnosed late. |
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| publishDate | 2021-02-01 |
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| series | Современная ревматология |
| spelling | doaj.art-66a291585d5349389205720d81025b1a2023-03-13T08:39:28ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-02-01151384510.14412/1996-7012-2021-1-38-452321Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patientsG. M. Koilubaeva0E. R. Karimova1S. K. Solovyev2E. A. Aseeva3F. S. Dzhuzenova4E. L. Nasonov5E. Zh. Dzhishambaev6D. A. Usupbaeva7A. K. Turusbekova8Национальный центр кардиологии и терапии им. академика Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республикиНациональный центр кардиологии и терапии им. академика Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республикиАО Группа компаний МЕДСИФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Национальный центр кардиологии и терапии им. академика Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республикиФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; Институт профессионального образования ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)Национальный центр кардиологии и терапии им. академика Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республикиНациональный центр кардиологии и терапии им. академика Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республикиНациональный центр кардиологии и терапии им. академика Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республикиObjective: to study clinical presentation, course variants and complications of Takayasu arteritis (AT) in Kyrgyz patients.Patients and methods. 75 Kyrgyz patients with a definite diagnosis of AT were included in the study, most of them were women (93.3%). The median age was 33 [23; 40] years, the median duration of the disease was 7 [3.0; 13.0] years. The anatomical type of vascular lesions was determined using the angiographic classification of R. Moriwaki et al., the AT activity – according to the BVAS index, the clinical stage of AT – using the R. Jefferson classification, the severity and prognosis of the disease – according to the K. Ishikawa classification. Highly sensitivity CRP (hsCRP) was assessed in 44 (58.67%) patients, interleukin 6 (IL6) – in 26 (34.7%). Instrumental procedures included duplex Doppler ultrasonography of peripheral arteries and contrast-enhanced computed pan aortography.Results and discussion. The mean age of AT onset was 24.4±9.4 years. The majority of patients had V anatomical type of vascular lesions (61.3%), vascular stage (89.3%), severe stenosis (54.7%) with predominant affection of the brachiocephalic trunk (68%), common carotid arteries (53.7 %) and renal (52%) arteries. Most patients (82.7%) at the time of inclusion in the study had a severe exacerbation of AT according to the BVAS index. An increase in hsCRP level was seen in 66% of cases, IL6 – in 31%. At the onset of AT, 20% of patients had fever, general weakness, weight loss, myalgia and/or arthralgia. 43% of patients had ≥2 complications. The clinical manifestations of AT were mainly characterized by cardiovascular pathology (77.3%) with the formation of relative aortic valve insufficiency (AVI) (93.1%) and kidney damage (57.3%) with the development of renovascular arterial hypertension (91%). At the first visit, more than one third of patients (37.3%) had irreversible damage, accompanied in half of them by AVI degree II or III.Conclusion. Young women predominated among Kyrgyz patients with AT. Most of the patients had anatomical type V AT (61.3%), vascular stage (89.3%), severe stenosis (54.7%), affection of the brachiocephalic trunk (68%), common carotid (57.3%) and renal (52%) arteries. Severe exacerbation of the disease was observed in 82.7% of patients. The presence of ≥2 complications worsened the prognosis of AT. The clinical manifestations of AT were characterized mainly by cardiovascular pathology (77.3%) and kidney damage (57.3%). In more than one third of patients (37.3%) AT was diagnosed late.https://mrj.ima-press.net/mrj/article/view/1098артериит такаясуактивностьстенозокклюзияаневризмаосложнениявазоренальная артериальная гипертензия |
| spellingShingle | G. M. Koilubaeva E. R. Karimova S. K. Solovyev E. A. Aseeva F. S. Dzhuzenova E. L. Nasonov E. Zh. Dzhishambaev D. A. Usupbaeva A. K. Turusbekova Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patients Современная ревматология артериит такаясу активность стеноз окклюзия аневризма осложнения вазоренальная артериальная гипертензия |
| title | Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patients |
| title_full | Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patients |
| title_fullStr | Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patients |
| title_full_unstemmed | Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patients |
| title_short | Clinical manifestations, course variants and complications of Takayasu arteritis in Kyrgyz patients |
| title_sort | clinical manifestations course variants and complications of takayasu arteritis in kyrgyz patients |
| topic | артериит такаясу активность стеноз окклюзия аневризма осложнения вазоренальная артериальная гипертензия |
| url | https://mrj.ima-press.net/mrj/article/view/1098 |
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