Evaluation of DNA damage induced by perfluorooctanoic acid using acellular, cellular, and in vivo comet assays

Evaluation of DNA damage induced by perfluorooctanoic acid using acellular, cellular, and in vivo comet assays

ObjectiveTo examine perfluorooctanoic acid （PFOA）-induced DNA damage using a combined in vivo and in vitro experiment.MethodsAcellular nuclear DNA damage was used as a model to test the damage induced by exposure to 0.00， 0.13， 0.25， and 0.50 mmol/L PFOA for 1 h. The YAC-1 cell was used as the resea...

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Bibliographic Details
Main Authors: WANG Qian, XU Tongguang, WANG Tianwei, CHEN Huihui, ZHANG Wenzhong
Format: Article
Language:zho
Published: The Editorial Office of Chinese Journal of Food Hygiene 2023-07-01
Series:Zhongguo shipin weisheng zazhi
Subjects:
perfluorooctanoic acid
dna damage
acellular comet assay
comet assay
micronucleus test
Online Access:http://www.zgspws.com/zgspwszz/article/abstract/202307002

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