Honey and Cancer: Current Status and Future Directions
Cancer is a leading cause of death worldwide and poses a challenge to treatment. With overwhelming evidence of the role played by diet and lifestyle in cancer risk and prevention, there is a growing interest into the search for chemopreventative or chemotherapeutic agents derived from natural produc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-09-01
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| Series: | Diseases |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-9721/4/4/30 |
| _version_ | 1818548220334178304 |
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| author | Laura M. Porcza Claire Simms Mridula Chopra |
| author_facet | Laura M. Porcza Claire Simms Mridula Chopra |
| author_sort | Laura M. Porcza |
| collection | DOAJ |
| description | Cancer is a leading cause of death worldwide and poses a challenge to treatment. With overwhelming evidence of the role played by diet and lifestyle in cancer risk and prevention, there is a growing interest into the search for chemopreventative or chemotherapeutic agents derived from natural products. Honey is an important source of bioactive compounds derived from plants and recent years have seen an increased interest in its anticancer properties. This review examines the role of honey in targeting key hallmarks of carcinogenesis, including uncontrolled proliferation, apoptosis evasion, angiogenesis, growth factor signalling, invasion, and inflammation. The evidence for honey as an adjunct to conventional cancer therapy is also presented. The review also highlights gaps in the current understanding and concludes that, before translation of evidence from cell culture and animal studies into the clinical setting, further studies are warranted to examine the effects of honey at a molecular level, as well as on cells in the tumour environment. |
| first_indexed | 2024-12-12T08:17:01Z |
| format | Article |
| id | doaj.art-66a4cab2ad744313b1af77156c8cfc24 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-12-12T08:17:01Z |
| publishDate | 2016-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-66a4cab2ad744313b1af77156c8cfc242022-12-22T00:31:32ZengMDPI AGDiseases2079-97212016-09-01443010.3390/diseases4040030diseases4040030Honey and Cancer: Current Status and Future DirectionsLaura M. Porcza0Claire Simms1Mridula Chopra2Institute of Biomedical and Biomolecular Science (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, Portsmouth PO1 2DT, UKInstitute of Biomedical and Biomolecular Science (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, Portsmouth PO1 2DT, UKInstitute of Biomedical and Biomolecular Science (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, Portsmouth PO1 2DT, UKCancer is a leading cause of death worldwide and poses a challenge to treatment. With overwhelming evidence of the role played by diet and lifestyle in cancer risk and prevention, there is a growing interest into the search for chemopreventative or chemotherapeutic agents derived from natural products. Honey is an important source of bioactive compounds derived from plants and recent years have seen an increased interest in its anticancer properties. This review examines the role of honey in targeting key hallmarks of carcinogenesis, including uncontrolled proliferation, apoptosis evasion, angiogenesis, growth factor signalling, invasion, and inflammation. The evidence for honey as an adjunct to conventional cancer therapy is also presented. The review also highlights gaps in the current understanding and concludes that, before translation of evidence from cell culture and animal studies into the clinical setting, further studies are warranted to examine the effects of honey at a molecular level, as well as on cells in the tumour environment.http://www.mdpi.com/2079-9721/4/4/30honeycancerphenolicflavonoidproliferationinflammationapoptosisangiogenesisfibrobalstsinvasion |
| spellingShingle | Laura M. Porcza Claire Simms Mridula Chopra Honey and Cancer: Current Status and Future Directions Diseases honey cancer phenolic flavonoid proliferation inflammation apoptosis angiogenesis fibrobalsts invasion |
| title | Honey and Cancer: Current Status and Future Directions |
| title_full | Honey and Cancer: Current Status and Future Directions |
| title_fullStr | Honey and Cancer: Current Status and Future Directions |
| title_full_unstemmed | Honey and Cancer: Current Status and Future Directions |
| title_short | Honey and Cancer: Current Status and Future Directions |
| title_sort | honey and cancer current status and future directions |
| topic | honey cancer phenolic flavonoid proliferation inflammation apoptosis angiogenesis fibrobalsts invasion |
| url | http://www.mdpi.com/2079-9721/4/4/30 |
| work_keys_str_mv | AT lauramporcza honeyandcancercurrentstatusandfuturedirections AT clairesimms honeyandcancercurrentstatusandfuturedirections AT mridulachopra honeyandcancercurrentstatusandfuturedirections |