Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links
Skeletal muscle atrophy in an inevitable occurrence with advancing age, and a consequence of disease including cancer. Muscle atrophy in the elderly is managed by a regimen of resistance exercise and increased protein intake. Understanding the signaling that regulates muscle mass may identify potent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/12/5/688 |
| _version_ | 1797535362042560512 |
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| author | Eun-Joo Lee Ronald L. Neppl |
| author_facet | Eun-Joo Lee Ronald L. Neppl |
| author_sort | Eun-Joo Lee |
| collection | DOAJ |
| description | Skeletal muscle atrophy in an inevitable occurrence with advancing age, and a consequence of disease including cancer. Muscle atrophy in the elderly is managed by a regimen of resistance exercise and increased protein intake. Understanding the signaling that regulates muscle mass may identify potential therapeutic targets for the prevention and reversal of muscle atrophy in metabolic and neuromuscular diseases. This review covers the major anabolic and catabolic pathways that regulate skeletal muscle mass, with a focus on recent progress and potential new players. |
| first_indexed | 2024-03-10T11:43:22Z |
| format | Article |
| id | doaj.art-66a6c21480d94659a0ff1c4cc60c766a |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T11:43:22Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-66a6c21480d94659a0ff1c4cc60c766a2023-11-21T18:16:37ZengMDPI AGGenes2073-44252021-05-0112568810.3390/genes12050688Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected LinksEun-Joo Lee0Ronald L. Neppl1Department of Orthopaedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Orthopaedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USASkeletal muscle atrophy in an inevitable occurrence with advancing age, and a consequence of disease including cancer. Muscle atrophy in the elderly is managed by a regimen of resistance exercise and increased protein intake. Understanding the signaling that regulates muscle mass may identify potential therapeutic targets for the prevention and reversal of muscle atrophy in metabolic and neuromuscular diseases. This review covers the major anabolic and catabolic pathways that regulate skeletal muscle mass, with a focus on recent progress and potential new players.https://www.mdpi.com/2073-4425/12/5/688Akt signalingmuscle atrophymuscle hypertrophyIGF-1/PI3K signalingaging muscleRNA-binding proteins |
| spellingShingle | Eun-Joo Lee Ronald L. Neppl Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links Genes Akt signaling muscle atrophy muscle hypertrophy IGF-1/PI3K signaling aging muscle RNA-binding proteins |
| title | Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links |
| title_full | Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links |
| title_fullStr | Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links |
| title_full_unstemmed | Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links |
| title_short | Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links |
| title_sort | influence of age on skeletal muscle hypertrophy and atrophy signaling established paradigms and unexpected links |
| topic | Akt signaling muscle atrophy muscle hypertrophy IGF-1/PI3K signaling aging muscle RNA-binding proteins |
| url | https://www.mdpi.com/2073-4425/12/5/688 |
| work_keys_str_mv | AT eunjoolee influenceofageonskeletalmusclehypertrophyandatrophysignalingestablishedparadigmsandunexpectedlinks AT ronaldlneppl influenceofageonskeletalmusclehypertrophyandatrophysignalingestablishedparadigmsandunexpectedlinks |