REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD
The article reviews the literature on classical and atypical Reye’s syndrome, explores the circumstances that contribute to its occurrence, provides criteria for diagnosing with an illustration in the form of an authentic case of Reye-like disease in a child of 3 years old. Reye’s syndrome is a di...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2018-09-01
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| Series: | Безопасность и риск фармакотерапии |
| Subjects: | |
| Online Access: | https://www.risksafety.ru/jour/article/view/109 |
| _version_ | 1797224609904328704 |
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| author | S. S. Postnikov S. V. Mikhailova G. P. Bryusov M. N. Kostyleva A. N. Gratsianskaya A. E. Ermilin |
| author_facet | S. S. Postnikov S. V. Mikhailova G. P. Bryusov M. N. Kostyleva A. N. Gratsianskaya A. E. Ermilin |
| author_sort | S. S. Postnikov |
| collection | DOAJ |
| description | The article reviews the literature on classical and atypical Reye’s syndrome, explores the circumstances that contribute to its occurrence, provides criteria for diagnosing with an illustration in the form of an authentic case of Reye-like disease in a child of 3 years old. Reye’s syndrome is a disease manifested by acute encephalopathy in combination with fatty degeneration of the internal organs, mainly the liver. This condition was first described in 1963 by an Australian pathologist who identified 21 cases of the disease in children with influenza A who were taking acetylsalicylic acid, 17 children died. In the future, the circle of infections that preceded the development of Reye’s syndrome-acute respiratory infections, chickenpox, entero- and rotavirus infections, in rare cases, hepatitis A and HIV, bacterial infections: mycoplasma, chlamydia, whooping cough, shigella, salmonella. Drugs that can cause the development of this syndrome: tetracycline, zidovudine, diclofenac sodium, mefenamic acid, paracetamol, amiodarone, warfarin, phenothiazine derivatives, histaminolytics (dimedrol), valproic acid. Along with drugs, insecticides, herbicides, hepatotoxic fungi can be used as triggers of the syndrome. There is an age dependence of the development of this syndrome. The pathogenesis of classic Reye’s syndrome is associated with generalized damage to the mitochondria primarily in the brain, as well as in the liver, kidneys, muscles, myocardium and pancreas, with the disturbance of oxidation of fatty acids in them and the formation of fat degeneration of varying degrees. In addition to the classic Reye’s syndrome, atypical Reye’s syndrome or Reye-like disease is isolated, occurs in children under 5 with congenital disturbance of oxidation of fatty acids. We observed in our clinic the case of Reye-like disease in a girl of three years with infection and taking antipyretics. In the discussion section, the features of the given case are noted, the question of the appropriateness (in view of the generality of the clinic and the mechanisms of development) of dividing the syndrome into classical and atypical is discussed. A new name for both conditions is proposed — Reye’s disease in honor of the discoverer, highlighting its two forms with an early and late onset. Given the morphological changes in this syndrome — steatosis of internal organs — authors seem to be appropriate measures aimed at treating secondary mitochondrial insufficiency and fatty dystrophy. |
| first_indexed | 2024-03-08T22:27:23Z |
| format | Article |
| id | doaj.art-66a77ea126ea4e7e8309c26413d2f1ac |
| institution | Directory Open Access Journal |
| issn | 2312-7821 2619-1164 |
| language | Russian |
| last_indexed | 2024-04-24T13:55:51Z |
| publishDate | 2018-09-01 |
| publisher | Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Безопасность и риск фармакотерапии |
| spelling | doaj.art-66a77ea126ea4e7e8309c26413d2f1ac2024-04-03T17:56:36ZrusMinistry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Безопасность и риск фармакотерапии2312-78212619-11642018-09-016310311010.30895/2312-7821-2018-6-3-103-110109REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILDS. S. Postnikov0S. V. Mikhailova1G. P. Bryusov2M. N. Kostyleva3A. N. Gratsianskaya4A. E. Ermilin5Federal State Budget Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» Ministry of Health of the Russian Federation Federal State Budgetary Institution Russian Children’s Clinical Hospital Ministry of Health of the Russian FederationFederal State Budgetary Institution Russian Children’s Clinical Hospital Ministry of Health of the Russian FederationFederal State Budgetary Institution Russian Children’s Clinical Hospital Ministry of Health of the Russian FederationFederal State Budget Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» Ministry of Health of the Russian Federation Federal State Budgetary Institution Russian Children’s Clinical Hospital Ministry of Health of the Russian FederationFederal State Budget Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» Ministry of Health of the Russian FederationFederal State Budget Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» Ministry of Health of the Russian FederationThe article reviews the literature on classical and atypical Reye’s syndrome, explores the circumstances that contribute to its occurrence, provides criteria for diagnosing with an illustration in the form of an authentic case of Reye-like disease in a child of 3 years old. Reye’s syndrome is a disease manifested by acute encephalopathy in combination with fatty degeneration of the internal organs, mainly the liver. This condition was first described in 1963 by an Australian pathologist who identified 21 cases of the disease in children with influenza A who were taking acetylsalicylic acid, 17 children died. In the future, the circle of infections that preceded the development of Reye’s syndrome-acute respiratory infections, chickenpox, entero- and rotavirus infections, in rare cases, hepatitis A and HIV, bacterial infections: mycoplasma, chlamydia, whooping cough, shigella, salmonella. Drugs that can cause the development of this syndrome: tetracycline, zidovudine, diclofenac sodium, mefenamic acid, paracetamol, amiodarone, warfarin, phenothiazine derivatives, histaminolytics (dimedrol), valproic acid. Along with drugs, insecticides, herbicides, hepatotoxic fungi can be used as triggers of the syndrome. There is an age dependence of the development of this syndrome. The pathogenesis of classic Reye’s syndrome is associated with generalized damage to the mitochondria primarily in the brain, as well as in the liver, kidneys, muscles, myocardium and pancreas, with the disturbance of oxidation of fatty acids in them and the formation of fat degeneration of varying degrees. In addition to the classic Reye’s syndrome, atypical Reye’s syndrome or Reye-like disease is isolated, occurs in children under 5 with congenital disturbance of oxidation of fatty acids. We observed in our clinic the case of Reye-like disease in a girl of three years with infection and taking antipyretics. In the discussion section, the features of the given case are noted, the question of the appropriateness (in view of the generality of the clinic and the mechanisms of development) of dividing the syndrome into classical and atypical is discussed. A new name for both conditions is proposed — Reye’s disease in honor of the discoverer, highlighting its two forms with an early and late onset. Given the morphological changes in this syndrome — steatosis of internal organs — authors seem to be appropriate measures aimed at treating secondary mitochondrial insufficiency and fatty dystrophy.https://www.risksafety.ru/jour/article/view/109reye’s syndromereye-like syndromerotavirus infectionneurodegenerative diseasemedicinal productsacetylsalicylic acidnonsteroidal anti-inflammatory drugs |
| spellingShingle | S. S. Postnikov S. V. Mikhailova G. P. Bryusov M. N. Kostyleva A. N. Gratsianskaya A. E. Ermilin REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD Безопасность и риск фармакотерапии reye’s syndrome reye-like syndrome rotavirus infection neurodegenerative disease medicinal products acetylsalicylic acid nonsteroidal anti-inflammatory drugs |
| title | REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD |
| title_full | REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD |
| title_fullStr | REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD |
| title_full_unstemmed | REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD |
| title_short | REYE-LIKE SYNDROME IN THREE-YEAR-OLD CHILD |
| title_sort | reye like syndrome in three year old child |
| topic | reye’s syndrome reye-like syndrome rotavirus infection neurodegenerative disease medicinal products acetylsalicylic acid nonsteroidal anti-inflammatory drugs |
| url | https://www.risksafety.ru/jour/article/view/109 |
| work_keys_str_mv | AT sspostnikov reyelikesyndromeinthreeyearoldchild AT svmikhailova reyelikesyndromeinthreeyearoldchild AT gpbryusov reyelikesyndromeinthreeyearoldchild AT mnkostyleva reyelikesyndromeinthreeyearoldchild AT angratsianskaya reyelikesyndromeinthreeyearoldchild AT aeermilin reyelikesyndromeinthreeyearoldchild |