Close-to-native bone repair via tissue-engineered endochondral ossification approaches
Summary: In order to solve the clinical challenges related to bone grafting, several tissue engineering (TE) strategies have been proposed to repair critical-sized defects. Generally, the classical TE approaches are designed to promote bone repair via intramembranous ossification. Although promising...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422201642X |
| _version_ | 1811247951392014336 |
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| author | Sara Nadine Inês J. Fernandes Clara R. Correia João F. Mano |
| author_facet | Sara Nadine Inês J. Fernandes Clara R. Correia João F. Mano |
| author_sort | Sara Nadine |
| collection | DOAJ |
| description | Summary: In order to solve the clinical challenges related to bone grafting, several tissue engineering (TE) strategies have been proposed to repair critical-sized defects. Generally, the classical TE approaches are designed to promote bone repair via intramembranous ossification. Although promising, strategies that direct the osteogenic differentiation of mesenchymal stem/stromal cells are usually characterized by a lack of functional vascular supply, often resulting in necrotic cores. A less explored alternative is engineering bone constructs through a cartilage-mediated approach, resembling the embryological process of endochondral ossification. The remodeling of an intermediary hypertrophic cartilaginous template triggers vascular invasion and bone tissue deposition. Thus, employing this knowledge can be a promising direction for the next generation of bone TE constructs. This review highlights the most recent biomimetic strategies for applying endochondral ossification in bone TE while discussing the plethora of cell types, culture conditions, and biomaterials essential to promote a successful bone regeneration process. |
| first_indexed | 2024-04-12T15:18:23Z |
| format | Article |
| id | doaj.art-66a854e5113a4e3c822ff2590efa46d9 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T15:18:23Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-66a854e5113a4e3c822ff2590efa46d92022-12-22T03:27:33ZengElsevieriScience2589-00422022-11-012511105370Close-to-native bone repair via tissue-engineered endochondral ossification approachesSara Nadine0Inês J. Fernandes1Clara R. Correia2João F. Mano3CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, PortugalCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, PortugalCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Corresponding authorCICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Corresponding authorSummary: In order to solve the clinical challenges related to bone grafting, several tissue engineering (TE) strategies have been proposed to repair critical-sized defects. Generally, the classical TE approaches are designed to promote bone repair via intramembranous ossification. Although promising, strategies that direct the osteogenic differentiation of mesenchymal stem/stromal cells are usually characterized by a lack of functional vascular supply, often resulting in necrotic cores. A less explored alternative is engineering bone constructs through a cartilage-mediated approach, resembling the embryological process of endochondral ossification. The remodeling of an intermediary hypertrophic cartilaginous template triggers vascular invasion and bone tissue deposition. Thus, employing this knowledge can be a promising direction for the next generation of bone TE constructs. This review highlights the most recent biomimetic strategies for applying endochondral ossification in bone TE while discussing the plethora of cell types, culture conditions, and biomaterials essential to promote a successful bone regeneration process.http://www.sciencedirect.com/science/article/pii/S258900422201642XHealth technologyTissue engineeringBiomaterials |
| spellingShingle | Sara Nadine Inês J. Fernandes Clara R. Correia João F. Mano Close-to-native bone repair via tissue-engineered endochondral ossification approaches iScience Health technology Tissue engineering Biomaterials |
| title | Close-to-native bone repair via tissue-engineered endochondral ossification approaches |
| title_full | Close-to-native bone repair via tissue-engineered endochondral ossification approaches |
| title_fullStr | Close-to-native bone repair via tissue-engineered endochondral ossification approaches |
| title_full_unstemmed | Close-to-native bone repair via tissue-engineered endochondral ossification approaches |
| title_short | Close-to-native bone repair via tissue-engineered endochondral ossification approaches |
| title_sort | close to native bone repair via tissue engineered endochondral ossification approaches |
| topic | Health technology Tissue engineering Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S258900422201642X |
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