Intestinal Immune Imbalance is an Alarm in the Development of IBD
Immune regulation plays a crucial role in human health and disease. Inflammatory bowel disease (IBD) is a chronic relapse bowel disease with an increasing incidence worldwide. Clinical treatments for IBD are limited and inefficient. However, the pathogenesis of immune-mediated IBD remains unclear. T...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/1073984 |
| _version_ | 1797751992601280512 |
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| author | Chunli Hu Shengtao Liao Lin Lv Chuanfei Li Zhechuan Mei |
| author_facet | Chunli Hu Shengtao Liao Lin Lv Chuanfei Li Zhechuan Mei |
| author_sort | Chunli Hu |
| collection | DOAJ |
| description | Immune regulation plays a crucial role in human health and disease. Inflammatory bowel disease (IBD) is a chronic relapse bowel disease with an increasing incidence worldwide. Clinical treatments for IBD are limited and inefficient. However, the pathogenesis of immune-mediated IBD remains unclear. This review describes the activation of innate and adaptive immune functions by intestinal immune cells to regulate intestinal immune balance and maintain intestinal mucosal integrity. Changes in susceptible genes, autophagy, energy metabolism, and other factors interact in a complex manner with the immune system, eventually leading to intestinal immune imbalance and the onset of IBD. These events indicate that intestinal immune imbalance is an alarm for IBD development, further opening new possibilities for the unprecedented development of immunotherapy for IBD. |
| first_indexed | 2024-03-12T16:57:44Z |
| format | Article |
| id | doaj.art-66a8cb267da340f1937862b9cc8518cd |
| institution | Directory Open Access Journal |
| issn | 1466-1861 |
| language | English |
| last_indexed | 2024-03-12T16:57:44Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj.art-66a8cb267da340f1937862b9cc8518cd2023-08-08T00:00:01ZengHindawi LimitedMediators of Inflammation1466-18612023-01-01202310.1155/2023/1073984Intestinal Immune Imbalance is an Alarm in the Development of IBDChunli Hu0Shengtao Liao1Lin Lv2Chuanfei Li3Zhechuan Mei4Department of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyImmune regulation plays a crucial role in human health and disease. Inflammatory bowel disease (IBD) is a chronic relapse bowel disease with an increasing incidence worldwide. Clinical treatments for IBD are limited and inefficient. However, the pathogenesis of immune-mediated IBD remains unclear. This review describes the activation of innate and adaptive immune functions by intestinal immune cells to regulate intestinal immune balance and maintain intestinal mucosal integrity. Changes in susceptible genes, autophagy, energy metabolism, and other factors interact in a complex manner with the immune system, eventually leading to intestinal immune imbalance and the onset of IBD. These events indicate that intestinal immune imbalance is an alarm for IBD development, further opening new possibilities for the unprecedented development of immunotherapy for IBD.http://dx.doi.org/10.1155/2023/1073984 |
| spellingShingle | Chunli Hu Shengtao Liao Lin Lv Chuanfei Li Zhechuan Mei Intestinal Immune Imbalance is an Alarm in the Development of IBD Mediators of Inflammation |
| title | Intestinal Immune Imbalance is an Alarm in the Development of IBD |
| title_full | Intestinal Immune Imbalance is an Alarm in the Development of IBD |
| title_fullStr | Intestinal Immune Imbalance is an Alarm in the Development of IBD |
| title_full_unstemmed | Intestinal Immune Imbalance is an Alarm in the Development of IBD |
| title_short | Intestinal Immune Imbalance is an Alarm in the Development of IBD |
| title_sort | intestinal immune imbalance is an alarm in the development of ibd |
| url | http://dx.doi.org/10.1155/2023/1073984 |
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