Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI
Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in human...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/27814 |
| _version_ | 1811252937924542464 |
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| author | Tomoki Arichi Kimberley Whitehead Giovanni Barone Ronit Pressler Francesco Padormo A David Edwards Lorenzo Fabrizi |
| author_facet | Tomoki Arichi Kimberley Whitehead Giovanni Barone Ronit Pressler Francesco Padormo A David Edwards Lorenzo Fabrizi |
| author_sort | Tomoki Arichi |
| collection | DOAJ |
| description | Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in humans has not yet been identified. Here, we use simultaneous EEG-fMRI to localise the source of delta brush events in 10 preterm infants aged 32–36 postmenstrual weeks. The most frequent patterns were left and right posterior-temporal delta brushes which were associated in the left hemisphere with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the insular and temporal cortices. This direct measure of neural and hemodynamic activity shows that the insula, one of the most densely connected hubs in the developing cortex, is a major source of the transient bursting events that are critical for brain maturation. |
| first_indexed | 2024-04-12T16:42:20Z |
| format | Article |
| id | doaj.art-66a959507c5546b3bed164cdceee6f86 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:42:20Z |
| publishDate | 2017-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-66a959507c5546b3bed164cdceee6f862022-12-22T03:24:43ZengeLife Sciences Publications LtdeLife2050-084X2017-09-01610.7554/eLife.27814Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRITomoki Arichi0https://orcid.org/0000-0002-3550-1644Kimberley Whitehead1Giovanni Barone2Ronit Pressler3Francesco Padormo4A David Edwards5https://orcid.org/0000-0003-4801-7066Lorenzo Fabrizi6https://orcid.org/0000-0002-9582-0727Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom; Department of Bioengineering, Imperial College London, London, United KingdomDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United KingdomCentre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom; Department of Pediatrics, Catholic University of Sacred Heart, Rome, ItalyClinical Neurosciences, UCL-Institute of Child Health, London, United KingdomCentre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom; Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, United StatesCentre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom; Department of Bioengineering, Imperial College London, London, United KingdomDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United KingdomElectroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in humans has not yet been identified. Here, we use simultaneous EEG-fMRI to localise the source of delta brush events in 10 preterm infants aged 32–36 postmenstrual weeks. The most frequent patterns were left and right posterior-temporal delta brushes which were associated in the left hemisphere with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the insular and temporal cortices. This direct measure of neural and hemodynamic activity shows that the insula, one of the most densely connected hubs in the developing cortex, is a major source of the transient bursting events that are critical for brain maturation.https://elifesciences.org/articles/27814EEGfMRIbrain developmentprematurityneonatespontaneous neuronal activity |
| spellingShingle | Tomoki Arichi Kimberley Whitehead Giovanni Barone Ronit Pressler Francesco Padormo A David Edwards Lorenzo Fabrizi Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI eLife EEG fMRI brain development prematurity neonate spontaneous neuronal activity |
| title | Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI |
| title_full | Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI |
| title_fullStr | Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI |
| title_full_unstemmed | Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI |
| title_short | Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI |
| title_sort | localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous eeg fmri |
| topic | EEG fMRI brain development prematurity neonate spontaneous neuronal activity |
| url | https://elifesciences.org/articles/27814 |
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