Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica
Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/8/7016 |
| _version_ | 1797605155305160704 |
|---|---|
| author | Ekaterina Martynova Robert J. Stott-Marshall Venera Shakirova Albina Saubanova Asiya Bulatova Yuriy N. Davidyuk Emmanuel Kabwe Maria Markelova Ilseyar Khaertynova Toshana L. Foster Svetlana Khaiboullina |
| author_facet | Ekaterina Martynova Robert J. Stott-Marshall Venera Shakirova Albina Saubanova Asiya Bulatova Yuriy N. Davidyuk Emmanuel Kabwe Maria Markelova Ilseyar Khaertynova Toshana L. Foster Svetlana Khaiboullina |
| author_sort | Ekaterina Martynova |
| collection | DOAJ |
| description | Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age category. Here, we have analyzed clinical and laboratory data in adults and children with NE to establish whether and how the disease severity differs between the two age groups. Serum cytokines were analyzed in samples collected from 11 children and 129 adult NE patients during an outbreak in 2019. A kidney toxicity panel was also used to analyze urine samples from these patients. Additionally, serum and urine samples were analyzed from 11 control children and 26 control adults. Analysis of clinical and laboratory data revealed that NE was milder in children than in adults. A variation in serum cytokine activation could explain the differences in clinical presentation. Cytokines associated with activation of Th1 lymphocytes were prominent in adults, while they were obscured in sera from pediatric NE patients. In addition, a prolonged activation of kidney injury markers was found in adults with NE, whilst only a short-lasting activation of these markers was observed in children with NE. These findings support previous observations of age differences in NE severity, which should be considered when diagnosing the disease in children. |
| first_indexed | 2024-03-11T04:57:06Z |
| format | Article |
| id | doaj.art-66aa4a7a15564edc8307fee6fc85f9ca |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:57:06Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-66aa4a7a15564edc8307fee6fc85f9ca2023-11-17T19:33:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248701610.3390/ijms24087016Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia EpidemicaEkaterina Martynova0Robert J. Stott-Marshall1Venera Shakirova2Albina Saubanova3Asiya Bulatova4Yuriy N. Davidyuk5Emmanuel Kabwe6Maria Markelova7Ilseyar Khaertynova8Toshana L. Foster9Svetlana Khaiboullina10“Gene and Cell Technologies” Institute of Fundamental Medicine and Biology, Kazan Federal University, OpenLab, 420008 Kazan, RussiaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UKState Medical Academy, 420012 Kazan, RussiaState Medical Academy, 420012 Kazan, RussiaState Medical Academy, 420012 Kazan, Russia“Gene and Cell Technologies” Institute of Fundamental Medicine and Biology, Kazan Federal University, OpenLab, 420008 Kazan, Russia“Gene and Cell Technologies” Institute of Fundamental Medicine and Biology, Kazan Federal University, OpenLab, 420008 Kazan, Russia“Gene and Cell Technologies” Institute of Fundamental Medicine and Biology, Kazan Federal University, OpenLab, 420008 Kazan, RussiaState Medical Academy, 420012 Kazan, RussiaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK“Gene and Cell Technologies” Institute of Fundamental Medicine and Biology, Kazan Federal University, OpenLab, 420008 Kazan, RussiaNephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age category. Here, we have analyzed clinical and laboratory data in adults and children with NE to establish whether and how the disease severity differs between the two age groups. Serum cytokines were analyzed in samples collected from 11 children and 129 adult NE patients during an outbreak in 2019. A kidney toxicity panel was also used to analyze urine samples from these patients. Additionally, serum and urine samples were analyzed from 11 control children and 26 control adults. Analysis of clinical and laboratory data revealed that NE was milder in children than in adults. A variation in serum cytokine activation could explain the differences in clinical presentation. Cytokines associated with activation of Th1 lymphocytes were prominent in adults, while they were obscured in sera from pediatric NE patients. In addition, a prolonged activation of kidney injury markers was found in adults with NE, whilst only a short-lasting activation of these markers was observed in children with NE. These findings support previous observations of age differences in NE severity, which should be considered when diagnosing the disease in children.https://www.mdpi.com/1422-0067/24/8/7016nephropathia epidemicacytokinepediatric |
| spellingShingle | Ekaterina Martynova Robert J. Stott-Marshall Venera Shakirova Albina Saubanova Asiya Bulatova Yuriy N. Davidyuk Emmanuel Kabwe Maria Markelova Ilseyar Khaertynova Toshana L. Foster Svetlana Khaiboullina Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica International Journal of Molecular Sciences nephropathia epidemica cytokine pediatric |
| title | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
| title_full | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
| title_fullStr | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
| title_full_unstemmed | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
| title_short | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
| title_sort | differential cytokine responses and the clinical severity of adult and pediatric nephropathia epidemica |
| topic | nephropathia epidemica cytokine pediatric |
| url | https://www.mdpi.com/1422-0067/24/8/7016 |
| work_keys_str_mv | AT ekaterinamartynova differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT robertjstottmarshall differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT venerashakirova differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT albinasaubanova differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT asiyabulatova differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT yuriyndavidyuk differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT emmanuelkabwe differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT mariamarkelova differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT ilseyarkhaertynova differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT toshanalfoster differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica AT svetlanakhaiboullina differentialcytokineresponsesandtheclinicalseverityofadultandpediatricnephropathiaepidemica |