Severe Hyperprolactinemia Promotes Brown Adipose Tissue Whitening and Aggravates High Fat Diet Induced Metabolic Imbalance

Severe Hyperprolactinemia Promotes Brown Adipose Tissue Whitening and Aggravates High Fat Diet Induced Metabolic Imbalance

BackgroundThe association of high serum prolactin and increased body weight is positive but controversial, therefore we hypothesized that additional factors such as diets and the impact of prolactin on brown adipose tissue may condition its metabolic effects.MethodsWe used LacDrd2KO females with lif...

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Bibliographic Details
Main Authors: Felicitas Lopez-Vicchi, Catalina De Winne, Ana Maria Ornstein, Eleonora Sorianello, Judith Toneatto, Damasia Becu-Villalobos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Endocrinology
Subjects:
prolactin
brown adipose tissue
thermogenic markers
whitening
UCP1
PGC1 alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.883092/full

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