Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review
The emergence of antimicrobial resistance raises the fear of untreatable diseases. Antimicrobial resistance is a multifaceted and dynamic phenomenon that is the cumulative result of different factors. While Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus and Clostridium...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korea Disease Control and Prevention Agency
2023-10-01
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| Series: | Osong Public Health and Research Perspectives |
| Subjects: | |
| Online Access: | http://ophrp.org/upload/pdf/j-phrp-2022-0323.pdf |
| _version_ | 1797628846478983168 |
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| author | Priyanka Bhowmik Barkha Modi Parijat Roy Antarika Chowdhury |
| author_facet | Priyanka Bhowmik Barkha Modi Parijat Roy Antarika Chowdhury |
| author_sort | Priyanka Bhowmik |
| collection | DOAJ |
| description | The emergence of antimicrobial resistance raises the fear of untreatable diseases. Antimicrobial resistance is a multifaceted and dynamic phenomenon that is the cumulative result of different factors. While Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus and Clostridium difficile, were previously the most concerning issues in the field of public health, Gram-negative pathogens are now of prime importance. The World Health Organization’s priority list of pathogens mostly includes multidrug-resistant Gram-negative organisms particularly carbapenem-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and extensively drug-resistant Acinetobacter baumannii. The spread of Gram-negative bacterial resistance is a global issue, involving a variety of mechanisms. Several strategies have been proposed to control resistant Gram-negative bacteria, such as the development of antimicrobial auxiliary agents and research into chemical compounds with new modes of action. Another emerging trend is the development of naturally derived antibacterial compounds that aim for targets novel areas, including engineered bacteriophages, probiotics, metal-based antibacterial agents, odilorhabdins, quorum sensing inhibitors, and microbiome-modifying agents. This review focuses on the current status of alternative treatment regimens against multidrug-resistant Gram-negative bacteria, aiming to provide a snapshot of the situation and some information on the broader context. |
| first_indexed | 2024-03-11T10:44:55Z |
| format | Article |
| id | doaj.art-66ab84f40c864407aa7b0ac04bf1a85b |
| institution | Directory Open Access Journal |
| issn | 2233-6052 |
| language | English |
| last_indexed | 2024-03-11T10:44:55Z |
| publishDate | 2023-10-01 |
| publisher | Korea Disease Control and Prevention Agency |
| record_format | Article |
| series | Osong Public Health and Research Perspectives |
| spelling | doaj.art-66ab84f40c864407aa7b0ac04bf1a85b2023-11-14T06:12:43ZengKorea Disease Control and Prevention AgencyOsong Public Health and Research Perspectives2233-60522023-10-0114533334610.24171/j.phrp.2022.0323740Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a reviewPriyanka Bhowmik0Barkha Modi1Parijat Roy2Antarika Chowdhury3 Department of Biological Sciences, School of Life Science & Biotechnology, Adamas University, Kolkata, India Department of Microbiology, Techno India University, Kolkata, India Department of Biological Sciences, School of Life Science & Biotechnology, Adamas University, Kolkata, India Department of Biological Sciences, School of Life Science & Biotechnology, Adamas University, Kolkata, IndiaThe emergence of antimicrobial resistance raises the fear of untreatable diseases. Antimicrobial resistance is a multifaceted and dynamic phenomenon that is the cumulative result of different factors. While Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus and Clostridium difficile, were previously the most concerning issues in the field of public health, Gram-negative pathogens are now of prime importance. The World Health Organization’s priority list of pathogens mostly includes multidrug-resistant Gram-negative organisms particularly carbapenem-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and extensively drug-resistant Acinetobacter baumannii. The spread of Gram-negative bacterial resistance is a global issue, involving a variety of mechanisms. Several strategies have been proposed to control resistant Gram-negative bacteria, such as the development of antimicrobial auxiliary agents and research into chemical compounds with new modes of action. Another emerging trend is the development of naturally derived antibacterial compounds that aim for targets novel areas, including engineered bacteriophages, probiotics, metal-based antibacterial agents, odilorhabdins, quorum sensing inhibitors, and microbiome-modifying agents. This review focuses on the current status of alternative treatment regimens against multidrug-resistant Gram-negative bacteria, aiming to provide a snapshot of the situation and some information on the broader context.http://ophrp.org/upload/pdf/j-phrp-2022-0323.pdfalternative therapiesantibiotic resistanceantimicrobialgram-negative bacteriamultidrug drug resistance |
| spellingShingle | Priyanka Bhowmik Barkha Modi Parijat Roy Antarika Chowdhury Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review Osong Public Health and Research Perspectives alternative therapies antibiotic resistance antimicrobial gram-negative bacteria multidrug drug resistance |
| title | Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review |
| title_full | Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review |
| title_fullStr | Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review |
| title_full_unstemmed | Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review |
| title_short | Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review |
| title_sort | strategies to combat gram negative bacterial resistance to conventional antibacterial drugs a review |
| topic | alternative therapies antibiotic resistance antimicrobial gram-negative bacteria multidrug drug resistance |
| url | http://ophrp.org/upload/pdf/j-phrp-2022-0323.pdf |
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