EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase
Humans with biallelic inactivating mutations in Epithelial Cell Adhesion Molecule (EpCAM) develop congenital tufting enteropathy (CTE). To gain mechanistic insights regarding EpCAM function in this disorder, we prepared intestinal epithelial cell (IEC) organoids and spheroids. IEC organoids and sphe...
Main Authors: | Takeshi Ouchi, Sohshi Morimura, Lukas E. Dow, Hiroyuki Miyoshi, Mark C. Udey |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/10/2/256 |
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