Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s disease
Abstract: Lipopolyplex is a core-shell structure composed of nucleic acid, polycation and lipid. As a non-viral gene delivery vector, lipopolyplex combining the advantages of polyplex and lipoplex has shown superior colloidal stability, reduced cytotoxicity, extremely high gene transfection efficien...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00068/full |
| _version_ | 1811212349212721152 |
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| author | Wei eChen Hui eLi Zhenguo eLiu Weien eYuan |
| author_facet | Wei eChen Hui eLi Zhenguo eLiu Weien eYuan |
| author_sort | Wei eChen |
| collection | DOAJ |
| description | Abstract: Lipopolyplex is a core-shell structure composed of nucleic acid, polycation and lipid. As a non-viral gene delivery vector, lipopolyplex combining the advantages of polyplex and lipoplex has shown superior colloidal stability, reduced cytotoxicity, extremely high gene transfection efficiency. Following intravenous administration, there are many strategies based on lipopolyplex to overcome the complex biological barriers in systemic gene delivery including condensation of nucleic acids into nanoparticles, long circulation, cell targeting, endosomal escape, release to cytoplasm and entry into cell nucleus. Parkinson’s disease is the second most common neurodegenerative disorder and severely influences the patients’ life quality. Current gene therapy clinical trials for Parkinson’s disease employing viral vectors didn’t achieve satisfactory efficacy. However, lipopolyplex may become a promising alternative approach owing to its stability in blood, ability to cross the blood-brain barrier and specific targeting to diseased brain cells. |
| first_indexed | 2024-04-12T05:28:00Z |
| format | Article |
| id | doaj.art-66ad75dd0924469faa8ea85d70e87728 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T05:28:00Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-66ad75dd0924469faa8ea85d70e877282022-12-22T03:46:13ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-04-01810.3389/fnagi.2016.00068183539Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s diseaseWei eChen0Hui eLi1Zhenguo eLiu2Weien eYuan3Xinhua Hospital, Shanghai JiaoTong University School of MedicineShanghai JiaoTong UniversityXinhua Hospital, Shanghai JiaoTong University School of MedicineShanghai JiaoTong UniversityAbstract: Lipopolyplex is a core-shell structure composed of nucleic acid, polycation and lipid. As a non-viral gene delivery vector, lipopolyplex combining the advantages of polyplex and lipoplex has shown superior colloidal stability, reduced cytotoxicity, extremely high gene transfection efficiency. Following intravenous administration, there are many strategies based on lipopolyplex to overcome the complex biological barriers in systemic gene delivery including condensation of nucleic acids into nanoparticles, long circulation, cell targeting, endosomal escape, release to cytoplasm and entry into cell nucleus. Parkinson’s disease is the second most common neurodegenerative disorder and severely influences the patients’ life quality. Current gene therapy clinical trials for Parkinson’s disease employing viral vectors didn’t achieve satisfactory efficacy. However, lipopolyplex may become a promising alternative approach owing to its stability in blood, ability to cross the blood-brain barrier and specific targeting to diseased brain cells.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00068/fullParkinson’s diseasegene deliveryBiological barriersblood brain barrier.Keywords: lipopolyplex |
| spellingShingle | Wei eChen Hui eLi Zhenguo eLiu Weien eYuan Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s disease Frontiers in Aging Neuroscience Parkinson’s disease gene delivery Biological barriers blood brain barrier. Keywords: lipopolyplex |
| title | Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s disease |
| title_full | Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s disease |
| title_fullStr | Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s disease |
| title_full_unstemmed | Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s disease |
| title_short | Lipopolyplex for therapeutic gene delivery and its application for the treatment of Parkinson’s disease |
| title_sort | lipopolyplex for therapeutic gene delivery and its application for the treatment of parkinson s disease |
| topic | Parkinson’s disease gene delivery Biological barriers blood brain barrier. Keywords: lipopolyplex |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00068/full |
| work_keys_str_mv | AT weiechen lipopolyplexfortherapeuticgenedeliveryanditsapplicationforthetreatmentofparkinsonsdisease AT huieli lipopolyplexfortherapeuticgenedeliveryanditsapplicationforthetreatmentofparkinsonsdisease AT zhenguoeliu lipopolyplexfortherapeuticgenedeliveryanditsapplicationforthetreatmentofparkinsonsdisease AT weieneyuan lipopolyplexfortherapeuticgenedeliveryanditsapplicationforthetreatmentofparkinsonsdisease |