Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance
Organ transplant rejection (OTR) is a complex immune reaction involving multiple cells, and it determines graft survival and patient prognosis. At present, most transplant recipients are administered a combination of immunosuppressive and biological agents to protect them from OTR. However, immunosu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095809921003891 |
| _version_ | 1818231456707641344 |
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| author | Xiaojie Gan Jian Gu Zheng Ju Ling Lu |
| author_facet | Xiaojie Gan Jian Gu Zheng Ju Ling Lu |
| author_sort | Xiaojie Gan |
| collection | DOAJ |
| description | Organ transplant rejection (OTR) is a complex immune reaction involving multiple cells, and it determines graft survival and patient prognosis. At present, most transplant recipients are administered a combination of immunosuppressive and biological agents to protect them from OTR. However, immunosuppressive agents negatively impact the immune system of the patients, causing them to suffer from serious complications, such as chronic infection and malignant tumors. Therefore, a thorough understanding of the mechanisms involved in immune tolerance and immune rejection with regard to organ transplant (OT) is essential for developing better treatment options and improving patient outcomes. This article reviews the role of immune cells in OTR and organ transplant tolerance (OTT), including the novel cell therapies that are currently under clinical trials for transplant recipients. |
| first_indexed | 2024-12-12T10:50:41Z |
| format | Article |
| id | doaj.art-66af5f1aa1774d27bb859f3cc984469e |
| institution | Directory Open Access Journal |
| issn | 2095-8099 |
| language | English |
| last_indexed | 2024-12-12T10:50:41Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Engineering |
| spelling | doaj.art-66af5f1aa1774d27bb859f3cc984469e2022-12-22T00:26:47ZengElsevierEngineering2095-80992022-03-01104456Diverse Roles of Immune Cells in Transplant Rejection and Immune ToleranceXiaojie Gan0Jian Gu1Zheng Ju2Ling Lu3Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing 210029, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing 210029, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing 210029, ChinaCorresponding author.; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing 210029, ChinaOrgan transplant rejection (OTR) is a complex immune reaction involving multiple cells, and it determines graft survival and patient prognosis. At present, most transplant recipients are administered a combination of immunosuppressive and biological agents to protect them from OTR. However, immunosuppressive agents negatively impact the immune system of the patients, causing them to suffer from serious complications, such as chronic infection and malignant tumors. Therefore, a thorough understanding of the mechanisms involved in immune tolerance and immune rejection with regard to organ transplant (OT) is essential for developing better treatment options and improving patient outcomes. This article reviews the role of immune cells in OTR and organ transplant tolerance (OTT), including the novel cell therapies that are currently under clinical trials for transplant recipients.http://www.sciencedirect.com/science/article/pii/S2095809921003891Immune cellsInnate immune cellsAdaptive immune cellsOrgan transplantImmune tolerance |
| spellingShingle | Xiaojie Gan Jian Gu Zheng Ju Ling Lu Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance Engineering Immune cells Innate immune cells Adaptive immune cells Organ transplant Immune tolerance |
| title | Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance |
| title_full | Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance |
| title_fullStr | Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance |
| title_full_unstemmed | Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance |
| title_short | Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance |
| title_sort | diverse roles of immune cells in transplant rejection and immune tolerance |
| topic | Immune cells Innate immune cells Adaptive immune cells Organ transplant Immune tolerance |
| url | http://www.sciencedirect.com/science/article/pii/S2095809921003891 |
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