Convection-enhanced delivery of AAV2-PrPshRNA in prion-infected mice.
Prion disease is caused by a single pathogenic protein (PrPSc), an abnormal conformer of the normal cellular prion protein PrPC. Depletion of PrPC in prion knockout mice makes them resistant to prion disease. Thus, gene silencing of the Prnp gene is a promising effective therapeutic approach. Here,...
Main Authors: | Misol Ahn, Krystyna Bajsarowicz, Abby Oehler, Azucena Lemus, Krystof Bankiewicz, Stephen J DeArmond |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4035323?pdf=render |
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