Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction
Background Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine whether volume changes occurred in the contralateral breast during hormonal or...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2018-09-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2018.00563 |
| _version_ | 1798005399000973312 |
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| author | Jung Youl Park Jae-Ho Chung Hyung Chul Lee Byung-Il Lee Seung-Ha Park Eul-Sik Yoon |
| author_facet | Jung Youl Park Jae-Ho Chung Hyung Chul Lee Byung-Il Lee Seung-Ha Park Eul-Sik Yoon |
| author_sort | Jung Youl Park |
| collection | DOAJ |
| description | Background Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine whether volume changes occurred in the contralateral breast during hormonal or other adjuvant therapies.
Methods This study reviewed 90 patients who underwent unilateral breast reconstruction between September 2012 and April 2018 using tissue expanders and a permanent implant after the surgical removal of breast cancer. The volume of the contralateral breast was measured using a cast before the first (tissue expander insertion) and second (permanent implant change) stages of surgery. Changes in breast volume were evaluated to determine whether adjuvant therapy such as hormonal therapy, chemotherapy, and radiation therapy influenced the volume of the contralateral breast.
Results The group receiving tamoxifen therapy demonstrated a significant decrease in volume compared with the group without tamoxifen (−7.8% vs. 1.0%; P=0.028). The aromatase inhibitor–treated group showed a significant increase in volume compared with those who did not receive therapy (−6.2% vs. 4.5%; P=0.023). There were no significant differences between groups treated with other hormonal therapy, chemotherapy, or radiation therapy.
Conclusions Patients who received tamoxifen therapy showed a significant decrease in volume in the contralateral breast, while no significant change in weight or body mass index was found. Our findings suggest that we should choose smaller implants for premenopausal patients, who have a high likelihood of receiving tamoxifen therapy. |
| first_indexed | 2024-04-11T12:39:45Z |
| format | Article |
| id | doaj.art-66b480c9d3ff4b17b41759be24b86f9d |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-11T12:39:45Z |
| publishDate | 2018-09-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-66b480c9d3ff4b17b41759be24b86f9d2022-12-22T04:23:32ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712018-09-01450543244010.5999/aps.2018.00563961Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstructionJung Youl Park0Jae-Ho Chung1Hyung Chul Lee2Byung-Il Lee3Seung-Ha ParkEul-Sik Yoon4Department of Plastic and Reconstructive Surgery, Korea University College Medicine, Seoul, KoreaDepartment of Plastic and Reconstructive Surgery, Korea University College Medicine, Seoul, KoreaDepartment of Plastic and Reconstructive Surgery, Korea University College Medicine, Seoul, KoreaDepartment of Plastic and Reconstructive Surgery, Korea University College Medicine, Seoul, KoreaDepartment of Plastic and Reconstructive Surgery, Korea University College Medicine, Seoul, KoreaBackground Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine whether volume changes occurred in the contralateral breast during hormonal or other adjuvant therapies. Methods This study reviewed 90 patients who underwent unilateral breast reconstruction between September 2012 and April 2018 using tissue expanders and a permanent implant after the surgical removal of breast cancer. The volume of the contralateral breast was measured using a cast before the first (tissue expander insertion) and second (permanent implant change) stages of surgery. Changes in breast volume were evaluated to determine whether adjuvant therapy such as hormonal therapy, chemotherapy, and radiation therapy influenced the volume of the contralateral breast. Results The group receiving tamoxifen therapy demonstrated a significant decrease in volume compared with the group without tamoxifen (−7.8% vs. 1.0%; P=0.028). The aromatase inhibitor–treated group showed a significant increase in volume compared with those who did not receive therapy (−6.2% vs. 4.5%; P=0.023). There were no significant differences between groups treated with other hormonal therapy, chemotherapy, or radiation therapy. Conclusions Patients who received tamoxifen therapy showed a significant decrease in volume in the contralateral breast, while no significant change in weight or body mass index was found. Our findings suggest that we should choose smaller implants for premenopausal patients, who have a high likelihood of receiving tamoxifen therapy.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2018.00563surgery, plasticreconstructive surgical proceduresmammaplastyhormone antagoniststamoxifen |
| spellingShingle | Jung Youl Park Jae-Ho Chung Hyung Chul Lee Byung-Il Lee Seung-Ha Park Eul-Sik Yoon Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction Archives of Plastic Surgery surgery, plastic reconstructive surgical procedures mammaplasty hormone antagonists tamoxifen |
| title | Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction |
| title_full | Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction |
| title_fullStr | Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction |
| title_full_unstemmed | Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction |
| title_short | Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction |
| title_sort | impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant based breast reconstruction |
| topic | surgery, plastic reconstructive surgical procedures mammaplasty hormone antagonists tamoxifen |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2018.00563 |
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