Severe hypothyroidism associated with the degree of edema in a patient with nephrosis

We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding pr...

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Bibliographic Details
Main Authors: Hiroyuki Kinoshita, Amiko Ishii, Akiko Hayakawa, Mutsuko Yasuda, Seiji Inoshita, Fumiatsu Yakushiji
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Clinics and Practice
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Online Access:https://www.clinicsandpractice.org/index.php/cp/article/view/137
Description
Summary:We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30-50% of the plasma. The concentrations of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were approximately 30-50% of the plasma. Hypothyroidism was associated with the degree of edema. After improving systemic edema, proteinuria remained unchanged but the patient did not require levothyroxine. We speculate that the large amount of transudation of thyroid hormones with their carrier proteins from the blood vessels to the third space (edema and pleural effusion), thereby reducing thyroid hormones in the plasma, was associated with hypothyroidism.
ISSN:2039-7275
2039-7283