NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor

NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor

Epigenetic modifiers of the histone deacetylase (HDAC) family are often dysregulated in cancer cells. Experiments with small molecule HDAC inhibitors (HDACi) have proven that HDACs are a vulnerability of transformed cells. We evaluated a novel hydroxamic acid-based HDACi (KH16; termed yanostat) in h...

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Bibliographic Details
Main Authors: Ramy Ashry, Al-Hassan M. Mustafa, Kristin Hausmann, Michael Linnebacher, Susanne Strand, Wolfgang Sippl, Matthias Wirth, Oliver H. Krämer
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
apoptosis
colon cancer
HDAC
HDACi
NOXA
pancreatic cancer
Online Access:https://www.mdpi.com/2072-6694/15/14/3650

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