Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex.

Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex.

The stabilization of the replisome complex is essential in order to achieve highly processive DNA replication and preserve genomic integrity. Conversely, it would also be advantageous for the cell to abrogate replisome functions to prevent inappropriate replication when fork progression is adversely...

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Bibliographic Details
Main Authors: Laura C Roseaulin, Chiaki Noguchi, Esteban Martinez, Melissa A Ziegler, Takashi Toda, Eishi Noguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3547854?pdf=render

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