Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes

Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes

We previously found that DNA methyltransferase 3a (DNMT3a) plays an important role in regulating embryonic cardiomyocyte gene expression, morphology, and function. In this study, we investigated the role of the most abundant DNMT in mammalian cells, DNMT1, in these processes. It is known that DNMT1...

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Bibliographic Details
Main Authors: Xiefan Fang, Ryan Poulsen, Lu Zhao, Jingjing Wang, Scott A. Rivkees, Christopher C. Wendler
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:FEBS Open Bio
Subjects:
DNA methylation
DNMT1
embryonic cardiomyocyte
gene expression
Online Access:https://doi.org/10.1002/2211-5463.13252

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