Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma
(1) Background: To investigate the value of pulsatile trabecular meshwork (TM) motion in predicting the diurnal intraocular pressure (IOP) fluctuation of primary open-angle glaucoma (POAG). (2) Methods: This cross-sectional study recruited 20 normal patients and 30 patients with POAG. Of the POAG gr...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/10/2696 |
| _version_ | 1797498942464720896 |
|---|---|
| author | Rong Du Chen Xin Jingjiang Xu Jianping Hu Huaizhou Wang Ningli Wang Murray Johnstone |
| author_facet | Rong Du Chen Xin Jingjiang Xu Jianping Hu Huaizhou Wang Ningli Wang Murray Johnstone |
| author_sort | Rong Du |
| collection | DOAJ |
| description | (1) Background: To investigate the value of pulsatile trabecular meshwork (TM) motion in predicting the diurnal intraocular pressure (IOP) fluctuation of primary open-angle glaucoma (POAG). (2) Methods: This cross-sectional study recruited 20 normal patients and 30 patients with POAG. Of the POAG group, 20 had stable diurnal IOP and 10 had high IOP fluctuation. A clinical prototype phase-sensitive optical coherence tomography (PhS-OCT) model was used to measure TM pulsatile motion with maximum velocity (MV) and cumulative displacement (CDisp). (3) Results: MV and CDisp were higher in the external region in both normal and POAG patients. All MV and CDisp reduced significantly in the POAG group (<i>p</i> < 0.001). In the POAG group, except MV in the external region (<i>p</i> = 0.085), MV and CDisp in the nasal area were significantly higher than those in the temporal area (<i>p</i> < 0.05). The MV and CDisp in the external region in the nasal area of POAG patients with high IOP fluctuation were much lower than those with stable IOP (<i>p</i><sub>EMV3</sub> = 0.031, <i>p</i><sub>ECDisp3</sub> < 0.001); (4) Conclusions: Pulsatile TM motion reduced in POAG patients relevant to the level of diurnal IOP fluctuation. This study presents the segmental variance of TM stiffness in human living eyes and suggests the clinical potential of the measurement of pulsatile TM motion with PhS-OCT for the evaluation of diurnal IOP fluctuation. |
| first_indexed | 2024-03-10T03:40:30Z |
| format | Article |
| id | doaj.art-66bed866fbe24dd993c13a076945405c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:40:30Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-66bed866fbe24dd993c13a076945405c2023-11-23T11:33:23ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110269610.3390/jcm11102696Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle GlaucomaRong Du0Chen Xin1Jingjiang Xu2Jianping Hu3Huaizhou Wang4Ningli Wang5Murray Johnstone6Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaSchool of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Ophthalmology, University of Washington, Seattle, WA 98195, USA(1) Background: To investigate the value of pulsatile trabecular meshwork (TM) motion in predicting the diurnal intraocular pressure (IOP) fluctuation of primary open-angle glaucoma (POAG). (2) Methods: This cross-sectional study recruited 20 normal patients and 30 patients with POAG. Of the POAG group, 20 had stable diurnal IOP and 10 had high IOP fluctuation. A clinical prototype phase-sensitive optical coherence tomography (PhS-OCT) model was used to measure TM pulsatile motion with maximum velocity (MV) and cumulative displacement (CDisp). (3) Results: MV and CDisp were higher in the external region in both normal and POAG patients. All MV and CDisp reduced significantly in the POAG group (<i>p</i> < 0.001). In the POAG group, except MV in the external region (<i>p</i> = 0.085), MV and CDisp in the nasal area were significantly higher than those in the temporal area (<i>p</i> < 0.05). The MV and CDisp in the external region in the nasal area of POAG patients with high IOP fluctuation were much lower than those with stable IOP (<i>p</i><sub>EMV3</sub> = 0.031, <i>p</i><sub>ECDisp3</sub> < 0.001); (4) Conclusions: Pulsatile TM motion reduced in POAG patients relevant to the level of diurnal IOP fluctuation. This study presents the segmental variance of TM stiffness in human living eyes and suggests the clinical potential of the measurement of pulsatile TM motion with PhS-OCT for the evaluation of diurnal IOP fluctuation.https://www.mdpi.com/2077-0383/11/10/2696trabecular meshworkphase-sensitive optical coherent tomographypulsatile motionIOP fluctuationprimary open-angle glaucoma |
| spellingShingle | Rong Du Chen Xin Jingjiang Xu Jianping Hu Huaizhou Wang Ningli Wang Murray Johnstone Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma Journal of Clinical Medicine trabecular meshwork phase-sensitive optical coherent tomography pulsatile motion IOP fluctuation primary open-angle glaucoma |
| title | Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma |
| title_full | Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma |
| title_fullStr | Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma |
| title_full_unstemmed | Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma |
| title_short | Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma |
| title_sort | pulsatile trabecular meshwork motion an indicator of intraocular pressure control in primary open angle glaucoma |
| topic | trabecular meshwork phase-sensitive optical coherent tomography pulsatile motion IOP fluctuation primary open-angle glaucoma |
| url | https://www.mdpi.com/2077-0383/11/10/2696 |
| work_keys_str_mv | AT rongdu pulsatiletrabecularmeshworkmotionanindicatorofintraocularpressurecontrolinprimaryopenangleglaucoma AT chenxin pulsatiletrabecularmeshworkmotionanindicatorofintraocularpressurecontrolinprimaryopenangleglaucoma AT jingjiangxu pulsatiletrabecularmeshworkmotionanindicatorofintraocularpressurecontrolinprimaryopenangleglaucoma AT jianpinghu pulsatiletrabecularmeshworkmotionanindicatorofintraocularpressurecontrolinprimaryopenangleglaucoma AT huaizhouwang pulsatiletrabecularmeshworkmotionanindicatorofintraocularpressurecontrolinprimaryopenangleglaucoma AT ningliwang pulsatiletrabecularmeshworkmotionanindicatorofintraocularpressurecontrolinprimaryopenangleglaucoma AT murrayjohnstone pulsatiletrabecularmeshworkmotionanindicatorofintraocularpressurecontrolinprimaryopenangleglaucoma |