Investigating the Link between Alpha-1 Antitrypsin and Human Neutrophil Elastase in Bronchoalveolar Lavage Fluid of COVID-19 Patients

Investigating the Link between Alpha-1 Antitrypsin and Human Neutrophil Elastase in Bronchoalveolar Lavage Fluid of COVID-19 Patients

Neutrophils play a pathogenic role in COVID-19 by releasing Neutrophils Extracellular Traps (NETs) or human neutrophil elastase (HNE). Given that HNE is inhibited by α1-antitrypsin (AAT), we aimed to assess the content of HNE, α1-antitrypsin (AAT) and HNE–AAT complexes (the AAT/HNE balance) in 33 br...

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Bibliographic Details
Main Authors: Maura D’Amato, Valentina Vertui, Laura Pandolfi, Sara Bozzini, Tommaso Fossali, Riccardo Colombo, Anna Aliberti, Marco Fumagalli, Paolo Iadarola, Camilla Didò, Simona Viglio, Federica Meloni
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Current Issues in Molecular Biology
Subjects:
lung
alpha-1-antitrypsin (AAT)
human neutrophil elastase (HNE)
COVID-19
broncho-alveolar lavage (BAL)
Neutrophils Extracellular Traps (NETs)
Online Access:https://www.mdpi.com/1467-3045/44/5/143

Internet

https://www.mdpi.com/1467-3045/44/5/143

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