Vaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free status
Abstract Background The goal of polio eradication is to complete elimination and containment of all wild, vaccine-related and Sabin polioviruses. Vaccine-derived poliovirus (VDPV) surveillance in China from 2001–2013 is summarized in this report, which has important implications for the global polio...
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BMC
2017-12-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2849-z |
| _version_ | 1818243350302556160 |
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| author | Hai-Bo Wang Hui-Ming Luo Li Li Chun-Xiang Fan Li-Xin Hao Chao Ma Qi-Ru Su Hong Yang Kathleen H. Reilly Hua-Qing Wang Ning Wen |
| author_facet | Hai-Bo Wang Hui-Ming Luo Li Li Chun-Xiang Fan Li-Xin Hao Chao Ma Qi-Ru Su Hong Yang Kathleen H. Reilly Hua-Qing Wang Ning Wen |
| author_sort | Hai-Bo Wang |
| collection | DOAJ |
| description | Abstract Background The goal of polio eradication is to complete elimination and containment of all wild, vaccine-related and Sabin polioviruses. Vaccine-derived poliovirus (VDPV) surveillance in China from 2001–2013 is summarized in this report, which has important implications for the global polio eradication initiative. Methods Acute flaccid paralysis (AFP) cases and their contacts with VDPVs isolated from fecal specimens were identified in our AFP surveillance system or by field investigation. Epidemiological and laboratory information for these children were analyzed and the reasons for the VDPV outbreak was explored. Results VDPVs were isolated from a total of 49 children in more than two-thirds of Chinese provinces from 2001–2013, including 15 VDPV cases, 15 non-polio AFP cases and 19 contacts of AFP cases or healthy subjects. A total of 3 circulating VDPVs (cVDPVs) outbreaks were reported in China, resulting in 6 cVDPVs cases who had not been vaccinated with oral attenuated poliomyelitis vaccine. Among the 4 immunodeficiency-associated VDPVs (iVDPVs) cases, the longest duration of virus excretion was about 20 months. In addition, one imported VDPV case from Myanmar was detected in Yunnan Province. Conclusions Until all wild, vaccine-related and Sabin polioviruses are eradicated in the world, high quality routine immunization and sensitive AFP surveillance should be maintained, focusing efforts on underserved populations in high risk areas. |
| first_indexed | 2024-12-12T13:59:44Z |
| format | Article |
| id | doaj.art-66bfd95902294210a37b8f731b7c9420 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T13:59:44Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-66bfd95902294210a37b8f731b7c94202022-12-22T00:22:21ZengBMCBMC Infectious Diseases1471-23342017-12-011711810.1186/s12879-017-2849-zVaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free statusHai-Bo Wang0Hui-Ming Luo1Li Li2Chun-Xiang Fan3Li-Xin Hao4Chao Ma5Qi-Ru Su6Hong Yang7Kathleen H. Reilly8Hua-Qing Wang9Ning Wen10Chinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionIndependent ConsultantChinese Center for Disease Control and PreventionChinese Center for Disease Control and PreventionAbstract Background The goal of polio eradication is to complete elimination and containment of all wild, vaccine-related and Sabin polioviruses. Vaccine-derived poliovirus (VDPV) surveillance in China from 2001–2013 is summarized in this report, which has important implications for the global polio eradication initiative. Methods Acute flaccid paralysis (AFP) cases and their contacts with VDPVs isolated from fecal specimens were identified in our AFP surveillance system or by field investigation. Epidemiological and laboratory information for these children were analyzed and the reasons for the VDPV outbreak was explored. Results VDPVs were isolated from a total of 49 children in more than two-thirds of Chinese provinces from 2001–2013, including 15 VDPV cases, 15 non-polio AFP cases and 19 contacts of AFP cases or healthy subjects. A total of 3 circulating VDPVs (cVDPVs) outbreaks were reported in China, resulting in 6 cVDPVs cases who had not been vaccinated with oral attenuated poliomyelitis vaccine. Among the 4 immunodeficiency-associated VDPVs (iVDPVs) cases, the longest duration of virus excretion was about 20 months. In addition, one imported VDPV case from Myanmar was detected in Yunnan Province. Conclusions Until all wild, vaccine-related and Sabin polioviruses are eradicated in the world, high quality routine immunization and sensitive AFP surveillance should be maintained, focusing efforts on underserved populations in high risk areas.http://link.springer.com/article/10.1186/s12879-017-2849-zVaccine derived poliovirusImportationChinaPolio eradicationWild poliovirus |
| spellingShingle | Hai-Bo Wang Hui-Ming Luo Li Li Chun-Xiang Fan Li-Xin Hao Chao Ma Qi-Ru Su Hong Yang Kathleen H. Reilly Hua-Qing Wang Ning Wen Vaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free status BMC Infectious Diseases Vaccine derived poliovirus Importation China Polio eradication Wild poliovirus |
| title | Vaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free status |
| title_full | Vaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free status |
| title_fullStr | Vaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free status |
| title_full_unstemmed | Vaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free status |
| title_short | Vaccine-derived poliovirus surveillance in China during 2001–2013: the potential challenge for maintaining polio free status |
| title_sort | vaccine derived poliovirus surveillance in china during 2001 2013 the potential challenge for maintaining polio free status |
| topic | Vaccine derived poliovirus Importation China Polio eradication Wild poliovirus |
| url | http://link.springer.com/article/10.1186/s12879-017-2849-z |
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