3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases
The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race. Coinciding with the pandemic, three dimensional (3D) human organoids technology has also gained traction in the field of infectious disease. An...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/7/1541 |
| _version_ | 1797407369187033088 |
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| author | Shirley Pei Shan Chia Sharleen Li Ying Kong Jeremy Kah Sheng Pang Boon-Seng Soh |
| author_facet | Shirley Pei Shan Chia Sharleen Li Ying Kong Jeremy Kah Sheng Pang Boon-Seng Soh |
| author_sort | Shirley Pei Shan Chia |
| collection | DOAJ |
| description | The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race. Coinciding with the pandemic, three dimensional (3D) human organoids technology has also gained traction in the field of infectious disease. An in vitro construct that can closely resemble the in vivo organ, organoid technology could bridge the gap between the traditional two-dimensional (2D) cell culture and animal models. By harnessing the multi-lineage characteristic of the organoid that allows for the recapitulation of the organotypic structure and functions, 3D human organoids have emerged as an essential tool in the field of infectious disease research. In this review, we will be providing a comparison between conventional systems and organoid models. We will also be highlighting how organoids played a role in modelling common infectious diseases and molecular mechanisms behind the pathogenesis of causative agents. Additionally, we present the limitations associated with the current organoid models and innovative strategies that could resolve these shortcomings. |
| first_indexed | 2024-03-09T03:40:24Z |
| format | Article |
| id | doaj.art-66c0442a33ab4c25abf504dfbd42f13b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T03:40:24Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-66c0442a33ab4c25abf504dfbd42f13b2023-12-03T14:41:28ZengMDPI AGBiomedicines2227-90592022-06-01107154110.3390/biomedicines100715413D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious DiseasesShirley Pei Shan Chia0Sharleen Li Ying Kong1Jeremy Kah Sheng Pang2Boon-Seng Soh3Disease Modeling and Therapeutics Laboratory, ASTAR Institute of Molecular and Cell Biology, Singapore 138673, SingaporeDisease Modeling and Therapeutics Laboratory, ASTAR Institute of Molecular and Cell Biology, Singapore 138673, SingaporeDisease Modeling and Therapeutics Laboratory, ASTAR Institute of Molecular and Cell Biology, Singapore 138673, SingaporeDisease Modeling and Therapeutics Laboratory, ASTAR Institute of Molecular and Cell Biology, Singapore 138673, SingaporeThe COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race. Coinciding with the pandemic, three dimensional (3D) human organoids technology has also gained traction in the field of infectious disease. An in vitro construct that can closely resemble the in vivo organ, organoid technology could bridge the gap between the traditional two-dimensional (2D) cell culture and animal models. By harnessing the multi-lineage characteristic of the organoid that allows for the recapitulation of the organotypic structure and functions, 3D human organoids have emerged as an essential tool in the field of infectious disease research. In this review, we will be providing a comparison between conventional systems and organoid models. We will also be highlighting how organoids played a role in modelling common infectious diseases and molecular mechanisms behind the pathogenesis of causative agents. Additionally, we present the limitations associated with the current organoid models and innovative strategies that could resolve these shortcomings.https://www.mdpi.com/2227-9059/10/7/1541organoidinfectious diseasesvirusesbacteriaparasitesfungi |
| spellingShingle | Shirley Pei Shan Chia Sharleen Li Ying Kong Jeremy Kah Sheng Pang Boon-Seng Soh 3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases Biomedicines organoid infectious diseases viruses bacteria parasites fungi |
| title | 3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases |
| title_full | 3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases |
| title_fullStr | 3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases |
| title_full_unstemmed | 3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases |
| title_short | 3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases |
| title_sort | 3d human organoids the next viral model for the molecular basis of infectious diseases |
| topic | organoid infectious diseases viruses bacteria parasites fungi |
| url | https://www.mdpi.com/2227-9059/10/7/1541 |
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