Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective
Abstract Persistent corneal pain (PCP) has excellent research prospects, especially the central sensitization mechanism of the trigeminal nerve, which is involved in migraine, corneal pain, and trigeminal neuralgia. The cornea has dense sensory innervation, and repeated corneal neuropathic pain has...
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Format: | Article |
Language: | English |
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Wiley
2023-12-01
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Series: | Brain-X |
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Online Access: | https://doi.org/10.1002/brx2.48 |
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author | Xiaoping Hong Fadian Ding Jie Xiong Yuyu Wu Wanzhu Chen |
author_facet | Xiaoping Hong Fadian Ding Jie Xiong Yuyu Wu Wanzhu Chen |
author_sort | Xiaoping Hong |
collection | DOAJ |
description | Abstract Persistent corneal pain (PCP) has excellent research prospects, especially the central sensitization mechanism of the trigeminal nerve, which is involved in migraine, corneal pain, and trigeminal neuralgia. The cornea has dense sensory innervation, and repeated corneal neuropathic pain has been associated with trigeminal nerve central sensitization, which is induced in PCP. The calcitonin gene‐related peptide (CGRP) is involved in corneal pain conduction, injury protection, and immune homeostasis. A high CGRP level maintains corneal pain perception and protects corneal epithelial cells. However, a persistently high CGRP level causes hypersensitivity of the corneal and trigeminal nerves, resulting in PCP. CGRP‐related drugs can effectively improve trigeminal nerve sensitization and relieve central sensitization‐related pain (PCP, migraine, and trigeminal neuralgia). Exploring the role of CGRP in PCP's pain sensitization mechanism is vital in the pain perception field, with the potential to improve the quality of life of patients with PCP and strengthen the understanding of CGRP's dual role in corneal pain. |
first_indexed | 2024-04-24T15:42:47Z |
format | Article |
id | doaj.art-66c08de220f54e45903aeb806a0ecf06 |
institution | Directory Open Access Journal |
issn | 2835-3153 |
language | English |
last_indexed | 2024-04-24T15:42:47Z |
publishDate | 2023-12-01 |
publisher | Wiley |
record_format | Article |
series | Brain-X |
spelling | doaj.art-66c08de220f54e45903aeb806a0ecf062024-04-01T19:00:02ZengWileyBrain-X2835-31532023-12-0114n/an/a10.1002/brx2.48Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspectiveXiaoping Hong0Fadian Ding1Jie Xiong2Yuyu Wu3Wanzhu Chen4Department of Ophthalmology The Second Affiliated Hospital of Fujian Medical University Fujian Medical University Quanzhou Fujian ChinaDepartment of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital Fujian Medical University Fuzhou Fujian ChinaDepartment of Rehabilitation First Affiliated Hospital of Nanchang University Nanchang Jiangxi ChinaDepartment of Ophthalmology The Second Affiliated Hospital of Fujian Medical University Fujian Medical University Quanzhou Fujian ChinaDepartment of Ophthalmology The Second Affiliated Hospital of Fujian Medical University Fujian Medical University Quanzhou Fujian ChinaAbstract Persistent corneal pain (PCP) has excellent research prospects, especially the central sensitization mechanism of the trigeminal nerve, which is involved in migraine, corneal pain, and trigeminal neuralgia. The cornea has dense sensory innervation, and repeated corneal neuropathic pain has been associated with trigeminal nerve central sensitization, which is induced in PCP. The calcitonin gene‐related peptide (CGRP) is involved in corneal pain conduction, injury protection, and immune homeostasis. A high CGRP level maintains corneal pain perception and protects corneal epithelial cells. However, a persistently high CGRP level causes hypersensitivity of the corneal and trigeminal nerves, resulting in PCP. CGRP‐related drugs can effectively improve trigeminal nerve sensitization and relieve central sensitization‐related pain (PCP, migraine, and trigeminal neuralgia). Exploring the role of CGRP in PCP's pain sensitization mechanism is vital in the pain perception field, with the potential to improve the quality of life of patients with PCP and strengthen the understanding of CGRP's dual role in corneal pain.https://doi.org/10.1002/brx2.48calcitonin gene‐related peptidecorneal protectionpersistent corneal paintargeted drug therapytrigeminal nerve sensitization |
spellingShingle | Xiaoping Hong Fadian Ding Jie Xiong Yuyu Wu Wanzhu Chen Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective Brain-X calcitonin gene‐related peptide corneal protection persistent corneal pain targeted drug therapy trigeminal nerve sensitization |
title | Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective |
title_full | Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective |
title_fullStr | Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective |
title_full_unstemmed | Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective |
title_short | Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective |
title_sort | calcitonin gene related peptide and persistent corneal pain a trigeminal nerve sensitization perspective |
topic | calcitonin gene‐related peptide corneal protection persistent corneal pain targeted drug therapy trigeminal nerve sensitization |
url | https://doi.org/10.1002/brx2.48 |
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