Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics
Lipoproteins are synthesized by the liver and secreted to plasma. Chronic alcoholic intoxication produces frequently cirrhosis and concomitantly alterations in liver metabolism. Thirty patients with alcoholic cirrhosis and 83 healthy controls were selected for this study. Apolipoprotein A1, B100, le...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2007-10-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119319039 |
| _version_ | 1818740961122975744 |
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| author | Abraham Lemberg Laura Schreier Salvador Romay Maria Alejandra Fernández Diego Rosello Soledad Gonzales Juan Carlos Perazzo Ester Julia Filinger Maria Lujan Tomaro |
| author_facet | Abraham Lemberg Laura Schreier Salvador Romay Maria Alejandra Fernández Diego Rosello Soledad Gonzales Juan Carlos Perazzo Ester Julia Filinger Maria Lujan Tomaro |
| author_sort | Abraham Lemberg |
| collection | DOAJ |
| description | Lipoproteins are synthesized by the liver and secreted to plasma. Chronic alcoholic intoxication produces frequently cirrhosis and concomitantly alterations in liver metabolism. Thirty patients with alcoholic cirrhosis and 83 healthy controls were selected for this study. Apolipoprotein A1, B100, lecithin cholesterol acyltransferase, responsible for cholesterol esterification and seudocholinesterase enzyme activity not related to lipid metabolism, as a referent of proteins synthesized by the liver were analyzed. In 7 patients serum tiobarbituric acids, catalase, glutathione peroxidase were measured, as exponent of the presence of oxidative stress. Our results showed a significant decrease in lipoproteins, lecithin cholesterol acyltransferase and seudocholinesterase activities. An increase in serum tiobarbituric acids and a decrease in both antioxidant enzymes were found as well. In conclusion, alcohol cirrhotic liver decreases the production of liver proteins including those related to lipid metabolism, allowing the formation of steatosis and/or necrosis. Moreover oxidative stress participate possible as a major mechanism in liver damage. |
| first_indexed | 2024-12-18T01:49:02Z |
| format | Article |
| id | doaj.art-66c183abc193426da3637fbde983f893 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-18T01:49:02Z |
| publishDate | 2007-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-66c183abc193426da3637fbde983f8932022-12-21T21:25:05ZengElsevierAnnals of Hepatology1665-26812007-10-0164227232Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhoticsAbraham Lemberg0Laura Schreier1Salvador Romay2Maria Alejandra Fernández3Diego Rosello4Soledad Gonzales5Juan Carlos Perazzo6Ester Julia Filinger7Maria Lujan Tomaro8Portal Hypertension Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina; Cátedra de Fisiopatología, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaDepartment of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaPortal Hypertension Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaPortal Hypertension Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaPortal Hypertension Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaDepartment of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaCátedra de Fisiopatología, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaCátedra de Farmacia Clinica and CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina; Address for correspondance:Portal Hypertension Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, ArgentinaLipoproteins are synthesized by the liver and secreted to plasma. Chronic alcoholic intoxication produces frequently cirrhosis and concomitantly alterations in liver metabolism. Thirty patients with alcoholic cirrhosis and 83 healthy controls were selected for this study. Apolipoprotein A1, B100, lecithin cholesterol acyltransferase, responsible for cholesterol esterification and seudocholinesterase enzyme activity not related to lipid metabolism, as a referent of proteins synthesized by the liver were analyzed. In 7 patients serum tiobarbituric acids, catalase, glutathione peroxidase were measured, as exponent of the presence of oxidative stress. Our results showed a significant decrease in lipoproteins, lecithin cholesterol acyltransferase and seudocholinesterase activities. An increase in serum tiobarbituric acids and a decrease in both antioxidant enzymes were found as well. In conclusion, alcohol cirrhotic liver decreases the production of liver proteins including those related to lipid metabolism, allowing the formation of steatosis and/or necrosis. Moreover oxidative stress participate possible as a major mechanism in liver damage.http://www.sciencedirect.com/science/article/pii/S1665268119319039Alcoholic cirrhosislipoproteinsoxidative stress |
| spellingShingle | Abraham Lemberg Laura Schreier Salvador Romay Maria Alejandra Fernández Diego Rosello Soledad Gonzales Juan Carlos Perazzo Ester Julia Filinger Maria Lujan Tomaro Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics Annals of Hepatology Alcoholic cirrhosis lipoproteins oxidative stress |
| title | Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics |
| title_full | Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics |
| title_fullStr | Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics |
| title_full_unstemmed | Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics |
| title_short | Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics |
| title_sort | involvement of serum apolipoprotein ai and b100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics |
| topic | Alcoholic cirrhosis lipoproteins oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119319039 |
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