Label-free microfluidic sorting of microparticles
Massive growth of the microfluidics field has triggered numerous advances in focusing, separating, ordering, concentrating, and mixing of microparticles. Microfluidic systems capable of performing these functions are rapidly finding applications in industrial, environmental, and biomedical fields. P...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2019-12-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/1.5120501 |
| _version_ | 1818493482140958720 |
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| author | Jian Zhou Prithviraj Mukherjee Hua Gao Qiyue Luan Ian Papautsky |
| author_facet | Jian Zhou Prithviraj Mukherjee Hua Gao Qiyue Luan Ian Papautsky |
| author_sort | Jian Zhou |
| collection | DOAJ |
| description | Massive growth of the microfluidics field has triggered numerous advances in focusing, separating, ordering, concentrating, and mixing of microparticles. Microfluidic systems capable of performing these functions are rapidly finding applications in industrial, environmental, and biomedical fields. Passive and label-free methods are one of the major categories of such systems that have received enormous attention owing to device operational simplicity and low costs. With new platforms continuously being proposed, our aim here is to provide an updated overview of the state of the art for passive label-free microparticle separation, with emphasis on performance and operational conditions. In addition to the now common separation approaches using Newtonian flows, such as deterministic lateral displacement, pinched flow fractionation, cross-flow filtration, hydrodynamic filtration, and inertial microfluidics, we also discuss separation approaches using non-Newtonian, viscoelastic flow. We then highlight the newly emerging approach based on shear-induced diffusion, which enables direct processing of complex samples such as untreated whole blood. Finally, we hope that an improved understanding of label-free passive sorting approaches can lead to sophisticated and useful platforms toward automation in industrial, environmental, and biomedical fields. |
| first_indexed | 2024-12-10T17:55:55Z |
| format | Article |
| id | doaj.art-66c293bcaf974fad93b1f2c1ddfccd2e |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-12-10T17:55:55Z |
| publishDate | 2019-12-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-66c293bcaf974fad93b1f2c1ddfccd2e2022-12-22T01:38:56ZengAIP Publishing LLCAPL Bioengineering2473-28772019-12-0134041504041504-2310.1063/1.5120501Label-free microfluidic sorting of microparticlesJian Zhou0Prithviraj Mukherjee1Hua Gao2Qiyue Luan3Ian Papautsky4Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USADepartment of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USADepartment of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USADepartment of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USADepartment of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USAMassive growth of the microfluidics field has triggered numerous advances in focusing, separating, ordering, concentrating, and mixing of microparticles. Microfluidic systems capable of performing these functions are rapidly finding applications in industrial, environmental, and biomedical fields. Passive and label-free methods are one of the major categories of such systems that have received enormous attention owing to device operational simplicity and low costs. With new platforms continuously being proposed, our aim here is to provide an updated overview of the state of the art for passive label-free microparticle separation, with emphasis on performance and operational conditions. In addition to the now common separation approaches using Newtonian flows, such as deterministic lateral displacement, pinched flow fractionation, cross-flow filtration, hydrodynamic filtration, and inertial microfluidics, we also discuss separation approaches using non-Newtonian, viscoelastic flow. We then highlight the newly emerging approach based on shear-induced diffusion, which enables direct processing of complex samples such as untreated whole blood. Finally, we hope that an improved understanding of label-free passive sorting approaches can lead to sophisticated and useful platforms toward automation in industrial, environmental, and biomedical fields.http://dx.doi.org/10.1063/1.5120501 |
| spellingShingle | Jian Zhou Prithviraj Mukherjee Hua Gao Qiyue Luan Ian Papautsky Label-free microfluidic sorting of microparticles APL Bioengineering |
| title | Label-free microfluidic sorting of microparticles |
| title_full | Label-free microfluidic sorting of microparticles |
| title_fullStr | Label-free microfluidic sorting of microparticles |
| title_full_unstemmed | Label-free microfluidic sorting of microparticles |
| title_short | Label-free microfluidic sorting of microparticles |
| title_sort | label free microfluidic sorting of microparticles |
| url | http://dx.doi.org/10.1063/1.5120501 |
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