Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes

Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes

Background: RNA interference (RNAi) has tremendous potential for investigating gene function and for developing new therapies. Primary human hepatocytes (PHH) are the “gold standard” for studying the regulation of hepatic metabolism in vitro. However, application of RNAi in PHH has some technical hu...

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Bibliographic Details
Main Authors: Maria Thomas, Jessica K. Rieger, Benjamin A. Kandel, Kathrin Klein, Ulrich M. Zanger
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Nuclear receptors
RNAi
Lentivirus
CAR
PPARα
miR-143
Primary human hepatocytes
Online Access:http://www.karger.com/Article/FullText/362976

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