Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes

Background: RNA interference (RNAi) has tremendous potential for investigating gene function and for developing new therapies. Primary human hepatocytes (PHH) are the “gold standard” for studying the regulation of hepatic metabolism in vitro. However, application of RNAi in PHH has some technical hu...

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Hlavní autoři: Maria Thomas, Jessica K. Rieger, Benjamin A. Kandel, Kathrin Klein, Ulrich M. Zanger
Médium: Článek
Jazyk:English
Vydáno: Cell Physiol Biochem Press GmbH & Co KG 2014-07-01
Edice:Cellular Physiology and Biochemistry
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On-line přístup:http://www.karger.com/Article/FullText/362976