Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes

Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes

Background: RNA interference (RNAi) has tremendous potential for investigating gene function and for developing new therapies. Primary human hepatocytes (PHH) are the “gold standard” for studying the regulation of hepatic metabolism in vitro. However, application of RNAi in PHH has some technical hu...

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Príomhchruthaitheoirí: Maria Thomas, Jessica K. Rieger, Benjamin A. Kandel, Kathrin Klein, Ulrich M. Zanger
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Cell Physiol Biochem Press GmbH & Co KG 2014-07-01
Sraith:Cellular Physiology and Biochemistry
Ábhair:
Nuclear receptors
RNAi
Lentivirus
CAR
PPARα
miR-143
Primary human hepatocytes
Rochtain ar líne:http://www.karger.com/Article/FullText/362976

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http://www.karger.com/Article/FullText/362976

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