| Summary: | An ideal wound dressing should not only have flexibility, adequate mechanical strength and adhesion ability but also possess antibacterial ability and biofunction. Herein, we prepared polyvinyl alcohol (PVA)-based hydrogel membranes with copper ion-loaded polydopamine (PDA@Cu) to simultaneously achieve antibacterial and pro-angiogenesis functions in a wound dressing. We prepared three porous PVA/PDA@Cu hydrogels with different concentrations of copper ion, namely PVA/PDA@Cu-1, PVA/PDA@Cu-2 and PVA/PDA@Cu-3. Although the incorporation of PDA@Cu slightly decreased the compressive mechanical strength, the tensile property of the PVA/PDA@Cu significantly increased, thereby enhancing the flexibility of the PVA hydrogel film. The hydrogel membranes had good biocompatibility, except PVA/PDA@Cu-3, which had toxic effects because of a high Cu concentration. The antibacterial effect of the membrane increased with the increasing Cu concentration. Owing to the photothermal property of PDA, the PVA/PDA@Cu hydrogel membranes show synergistic antibacterial ability. Furthermore, the PVA/PDA@Cu-1 and PVA/PDA@Cu-2 hydrogel membranes had pro-angiogenesis property. Results of in vivo experiments showed that PVA/PDA@Cu-2 achieved satisfactory repair outcomes for the bacterial infected wound with abundant collagen deposition and formation of neo-vessels. These results suggest that the PVA/PDA@Cu hydrogel membrane serves as a better platform for regeneration of the infected skin and thus will have a clinical application in the future.
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