Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how
Type 2 diabetes (T2D) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance. Mounting evidence has correlated T2D to alterations in the composition of gut microbiota. Accordingly, targeting the gut microbiota has become an emerging strategy for T2D management. The...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2022-06-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/6323 |
| _version_ | 1827317445470191616 |
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| author | Kaijian Hou Shuo Zhang Zezhen Wu Dan Zhu Fengwu Chen Zi-Ning Lei Weiting Liu Chuanxing Xiao Zhe-Sheng Chen |
| author_facet | Kaijian Hou Shuo Zhang Zezhen Wu Dan Zhu Fengwu Chen Zi-Ning Lei Weiting Liu Chuanxing Xiao Zhe-Sheng Chen |
| author_sort | Kaijian Hou |
| collection | DOAJ |
| description |
Type 2 diabetes (T2D) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance. Mounting evidence has correlated T2D to alterations in the composition of gut microbiota. Accordingly, targeting the gut microbiota has become an emerging strategy for T2D management. The aim of this article is to get a better insight into the rationale for targeting gut microbiota in T2D treatment. Thus, we herein reviewed the change of gut microbiota composition in T2D, factors shaping gut microbiota, and potential mechanisms behind the contribution of gut microbiota to T2D pathogenesis. At present, it has become possible to use intestinal microorganism capsules, bacteria liquid, and other preparations to carry out fecal microbiota transplantation for the treatment and intervention of T2D with insulin resistance and immune-mediated type 1 diabetes (T1D).
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| first_indexed | 2024-04-24T23:38:59Z |
| format | Article |
| id | doaj.art-66c4763f1065471fb5a2a4d7317c1317 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:38:59Z |
| publishDate | 2022-06-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-66c4763f1065471fb5a2a4d7317c13172024-03-15T13:31:12ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2022-06-0122310.17305/bjbms.2021.6323Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and howKaijian Hou0Shuo Zhang1Zezhen Wu2Dan Zhu3Fengwu Chen4Zi-Ning Lei5Weiting Liu6Chuanxing Xiao7Zhe-Sheng Chen8https://orcid.org/0000-0002-8289-097XDepartment of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong, China; Department of Endocrine and Metabolic Diseases, Shantou University Medical College, Shantou University, Shantou, Guangdong, ChinaDepartment of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong, China; Department of Endocrine and Metabolic Diseases, Shantou University Medical College, Shantou University, Shantou, Guangdong, ChinaDepartment of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong, China; Department of Endocrine and Metabolic Diseases, Shantou University Medical College, Shantou University, Shantou, Guangdong, ChinaDepartment of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong, ChinaDepartment of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong, ChinaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York, USADepartment of Teaching and Research Section, College of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaDepartment of Pharmacy, College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, ChinaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John’s University, Queens, NY, USA Type 2 diabetes (T2D) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance. Mounting evidence has correlated T2D to alterations in the composition of gut microbiota. Accordingly, targeting the gut microbiota has become an emerging strategy for T2D management. The aim of this article is to get a better insight into the rationale for targeting gut microbiota in T2D treatment. Thus, we herein reviewed the change of gut microbiota composition in T2D, factors shaping gut microbiota, and potential mechanisms behind the contribution of gut microbiota to T2D pathogenesis. At present, it has become possible to use intestinal microorganism capsules, bacteria liquid, and other preparations to carry out fecal microbiota transplantation for the treatment and intervention of T2D with insulin resistance and immune-mediated type 1 diabetes (T1D). https://www.bjbms.org/ojs/index.php/bjbms/article/view/6323Fecal Microbiota Transplantationintestinal microecologytype 2 diabetes |
| spellingShingle | Kaijian Hou Shuo Zhang Zezhen Wu Dan Zhu Fengwu Chen Zi-Ning Lei Weiting Liu Chuanxing Xiao Zhe-Sheng Chen Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how Biomolecules & Biomedicine Fecal Microbiota Transplantation intestinal microecology type 2 diabetes |
| title | Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how |
| title_full | Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how |
| title_fullStr | Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how |
| title_full_unstemmed | Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how |
| title_short | Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how |
| title_sort | reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation why and how |
| topic | Fecal Microbiota Transplantation intestinal microecology type 2 diabetes |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/6323 |
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