Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of biologically active elements, making them a promising approach for therapeutics and diagnostics. This article examines...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/8/1250 |
| _version_ | 1797585313094172672 |
|---|---|
| author | Mahmoud Kandeel Mohamed A. Morsy Khalid M. Alkhodair Sameer Alhojaily |
| author_facet | Mahmoud Kandeel Mohamed A. Morsy Khalid M. Alkhodair Sameer Alhojaily |
| author_sort | Mahmoud Kandeel |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of biologically active elements, making them a promising approach for therapeutics and diagnostics. This article examines the potential therapeutic applications of MSC-derived EVs in addressing neurodegenerative disorders such as Alzheimer’s disease (AD), multiple sclerosis (MS), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Furthermore, the present state-of-the-art for MSC-EV-based therapy in AD, HD, PD, ALS, and MS is discussed. Significant progress has been made in understanding the etiology and potential treatments for a range of neurodegenerative diseases (NDs) over the last few decades. The contents of EVs are carried across cells for intercellular contact, which often results in the control of the recipient cell’s homeostasis. Since EVs represent the therapeutically beneficial cargo of parent cells and are devoid of many ethical problems connected with cell-based treatments, they offer a viable cell-free therapy alternative for tissue regeneration and repair. Developing innovative EV-dependent medicines has proven difficult due to the lack of standardized procedures in EV extraction processes as well as their pharmacological characteristics and mechanisms of action. However, recent biotechnology and engineering research has greatly enhanced the content and applicability of MSC-EVs. |
| first_indexed | 2024-03-11T00:05:23Z |
| format | Article |
| id | doaj.art-66c57fa79c7a41349af4ad536f768d0d |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T00:05:23Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-66c57fa79c7a41349af4ad536f768d0d2023-11-19T00:24:20ZengMDPI AGBiomolecules2218-273X2023-08-01138125010.3390/biom13081250Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative DisabilitiesMahmoud Kandeel0Mohamed A. Morsy1Khalid M. Alkhodair2Sameer Alhojaily3Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Anatomy, College of Veterinary Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaMesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of biologically active elements, making them a promising approach for therapeutics and diagnostics. This article examines the potential therapeutic applications of MSC-derived EVs in addressing neurodegenerative disorders such as Alzheimer’s disease (AD), multiple sclerosis (MS), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Furthermore, the present state-of-the-art for MSC-EV-based therapy in AD, HD, PD, ALS, and MS is discussed. Significant progress has been made in understanding the etiology and potential treatments for a range of neurodegenerative diseases (NDs) over the last few decades. The contents of EVs are carried across cells for intercellular contact, which often results in the control of the recipient cell’s homeostasis. Since EVs represent the therapeutically beneficial cargo of parent cells and are devoid of many ethical problems connected with cell-based treatments, they offer a viable cell-free therapy alternative for tissue regeneration and repair. Developing innovative EV-dependent medicines has proven difficult due to the lack of standardized procedures in EV extraction processes as well as their pharmacological characteristics and mechanisms of action. However, recent biotechnology and engineering research has greatly enhanced the content and applicability of MSC-EVs.https://www.mdpi.com/2218-273X/13/8/1250mesenchymal cellextracellular vesiclesneurodegenerative diseasestreatmentMSCs-based therapy |
| spellingShingle | Mahmoud Kandeel Mohamed A. Morsy Khalid M. Alkhodair Sameer Alhojaily Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities Biomolecules mesenchymal cell extracellular vesicles neurodegenerative diseases treatment MSCs-based therapy |
| title | Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities |
| title_full | Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities |
| title_fullStr | Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities |
| title_short | Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities |
| title_sort | mesenchymal stem cell derived extracellular vesicles an emerging diagnostic and therapeutic biomolecules for neurodegenerative disabilities |
| topic | mesenchymal cell extracellular vesicles neurodegenerative diseases treatment MSCs-based therapy |
| url | https://www.mdpi.com/2218-273X/13/8/1250 |
| work_keys_str_mv | AT mahmoudkandeel mesenchymalstemcellderivedextracellularvesiclesanemergingdiagnosticandtherapeuticbiomoleculesforneurodegenerativedisabilities AT mohamedamorsy mesenchymalstemcellderivedextracellularvesiclesanemergingdiagnosticandtherapeuticbiomoleculesforneurodegenerativedisabilities AT khalidmalkhodair mesenchymalstemcellderivedextracellularvesiclesanemergingdiagnosticandtherapeuticbiomoleculesforneurodegenerativedisabilities AT sameeralhojaily mesenchymalstemcellderivedextracellularvesiclesanemergingdiagnosticandtherapeuticbiomoleculesforneurodegenerativedisabilities |