Structural Vaccinology for Viral Vaccine Design
Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viru...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.00738/full |
| _version_ | 1818411611253112832 |
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| author | Mohd Ishtiaq Anasir Chit Laa Poh |
| author_facet | Mohd Ishtiaq Anasir Chit Laa Poh |
| author_sort | Mohd Ishtiaq Anasir |
| collection | DOAJ |
| description | Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viruses such as human immunodeficiency virus (HIV), hepatitis C virus, enterovirus A71, and dengue virus. Recent studies demonstrated that applications of this structural information can solve some of the vaccine conundrums. This review focuses on recent advances in structure-based vaccine design, or structural vaccinology, for novel and innovative viral vaccine design. |
| first_indexed | 2024-12-14T10:34:10Z |
| format | Article |
| id | doaj.art-66c789717a384f75bc3e83fb4b57fada |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T10:34:10Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-66c789717a384f75bc3e83fb4b57fada2022-12-21T23:06:00ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-04-011010.3389/fmicb.2019.00738438471Structural Vaccinology for Viral Vaccine DesignMohd Ishtiaq AnasirChit Laa PohAlthough vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viruses such as human immunodeficiency virus (HIV), hepatitis C virus, enterovirus A71, and dengue virus. Recent studies demonstrated that applications of this structural information can solve some of the vaccine conundrums. This review focuses on recent advances in structure-based vaccine design, or structural vaccinology, for novel and innovative viral vaccine design.https://www.frontiersin.org/article/10.3389/fmicb.2019.00738/fullstructural vaccinologyvaccine designprotein structureepitopevirus |
| spellingShingle | Mohd Ishtiaq Anasir Chit Laa Poh Structural Vaccinology for Viral Vaccine Design Frontiers in Microbiology structural vaccinology vaccine design protein structure epitope virus |
| title | Structural Vaccinology for Viral Vaccine Design |
| title_full | Structural Vaccinology for Viral Vaccine Design |
| title_fullStr | Structural Vaccinology for Viral Vaccine Design |
| title_full_unstemmed | Structural Vaccinology for Viral Vaccine Design |
| title_short | Structural Vaccinology for Viral Vaccine Design |
| title_sort | structural vaccinology for viral vaccine design |
| topic | structural vaccinology vaccine design protein structure epitope virus |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.00738/full |
| work_keys_str_mv | AT mohdishtiaqanasir structuralvaccinologyforviralvaccinedesign AT chitlaapoh structuralvaccinologyforviralvaccinedesign |