Longitudinal changes of lipid profile in the Lebanese pediatric population
Abstract Background Few studies looked at the prevalence of dyslipidemia in pediatric Middle-Eastern countries. In addition, worldwide longitudinal changes of lipid profile is not well documented. The purpose of this study is to look at the longitudinal changes of lipid parameters in Lebanese school...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-019-0991-x |
| _version_ | 1818524043087708160 |
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| author | Chloé Saadé Ghassan Sleilaty Marie-Hélène Gannagé-Yared |
| author_facet | Chloé Saadé Ghassan Sleilaty Marie-Hélène Gannagé-Yared |
| author_sort | Chloé Saadé |
| collection | DOAJ |
| description | Abstract Background Few studies looked at the prevalence of dyslipidemia in pediatric Middle-Eastern countries. In addition, worldwide longitudinal changes of lipid profile is not well documented. The purpose of this study is to look at the longitudinal changes of lipid parameters in Lebanese school-age children. Materials and methods A total of 97 subjects (41 girls and 56 boys) aged between 11 and 21 years were included in this study. The subjects were selected among 339 school-age children with a previous abnormal lipid profile who were recruited from 10 schools of varying socio-economic levels (SEL). A fasting lipid profile [total cholesterol (TC), triglycerides (TG) and HDL-cholesterol (HDL-C)] was performed. Non-HDL-cholesterol (Non-HDL-C) was calculated. Weight and height were measured under the same conditions, and BMI percentiles were calculated. A multivariate covariance analysis model (MANCOVA) was used with TG, HDL-C and non-HDL-C as dependent variables with additional post-MANCOVA F tests. Results The age of the current cohort is 16.5 ± 2.9 years with no significant difference according to gender. The current lipid profile was obtained 3.1 ± 0.7 years following the initial one, with 53.6% of the subjects having it normalized. TC, TG, and non-HDL-C decreased significantly over time in girls, while only TG decreased significantly in boys. No significant changes were observed for HDL-C. Using MANCOVA, a significant time by age interaction was observed (p < 0.0001), while gender, BMI and SEL were found not to be significant. Post-hoc F tests showed that the time by age interaction was driven by TG (p = 0.03) and non-HDL-C (p < 0.001), the larger effect being observed in younger children. Conclusion A high proportion of school-age children normalize their abnormal lipid profile with time. Screening for lipid disorders could be postponed until post puberty age. |
| first_indexed | 2024-12-11T05:52:17Z |
| format | Article |
| id | doaj.art-66c8855b7aeb4ee794a35b14033f712d |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-11T05:52:17Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-66c8855b7aeb4ee794a35b14033f712d2022-12-22T01:18:47ZengBMCLipids in Health and Disease1476-511X2019-02-011811710.1186/s12944-019-0991-xLongitudinal changes of lipid profile in the Lebanese pediatric populationChloé Saadé0Ghassan Sleilaty1Marie-Hélène Gannagé-Yared2Endocrinology Department, Faculty of Medicine, Saint Joseph University, Saint-JosephBiostatistics Department, Faculty of Medicine, Saint Joseph University, Saint-JosephEndocrinology Department, Faculty of Medicine, Saint Joseph University, Saint-JosephAbstract Background Few studies looked at the prevalence of dyslipidemia in pediatric Middle-Eastern countries. In addition, worldwide longitudinal changes of lipid profile is not well documented. The purpose of this study is to look at the longitudinal changes of lipid parameters in Lebanese school-age children. Materials and methods A total of 97 subjects (41 girls and 56 boys) aged between 11 and 21 years were included in this study. The subjects were selected among 339 school-age children with a previous abnormal lipid profile who were recruited from 10 schools of varying socio-economic levels (SEL). A fasting lipid profile [total cholesterol (TC), triglycerides (TG) and HDL-cholesterol (HDL-C)] was performed. Non-HDL-cholesterol (Non-HDL-C) was calculated. Weight and height were measured under the same conditions, and BMI percentiles were calculated. A multivariate covariance analysis model (MANCOVA) was used with TG, HDL-C and non-HDL-C as dependent variables with additional post-MANCOVA F tests. Results The age of the current cohort is 16.5 ± 2.9 years with no significant difference according to gender. The current lipid profile was obtained 3.1 ± 0.7 years following the initial one, with 53.6% of the subjects having it normalized. TC, TG, and non-HDL-C decreased significantly over time in girls, while only TG decreased significantly in boys. No significant changes were observed for HDL-C. Using MANCOVA, a significant time by age interaction was observed (p < 0.0001), while gender, BMI and SEL were found not to be significant. Post-hoc F tests showed that the time by age interaction was driven by TG (p = 0.03) and non-HDL-C (p < 0.001), the larger effect being observed in younger children. Conclusion A high proportion of school-age children normalize their abnormal lipid profile with time. Screening for lipid disorders could be postponed until post puberty age.http://link.springer.com/article/10.1186/s12944-019-0991-xLongitudinalLipidLebaneseSchool-age children |
| spellingShingle | Chloé Saadé Ghassan Sleilaty Marie-Hélène Gannagé-Yared Longitudinal changes of lipid profile in the Lebanese pediatric population Lipids in Health and Disease Longitudinal Lipid Lebanese School-age children |
| title | Longitudinal changes of lipid profile in the Lebanese pediatric population |
| title_full | Longitudinal changes of lipid profile in the Lebanese pediatric population |
| title_fullStr | Longitudinal changes of lipid profile in the Lebanese pediatric population |
| title_full_unstemmed | Longitudinal changes of lipid profile in the Lebanese pediatric population |
| title_short | Longitudinal changes of lipid profile in the Lebanese pediatric population |
| title_sort | longitudinal changes of lipid profile in the lebanese pediatric population |
| topic | Longitudinal Lipid Lebanese School-age children |
| url | http://link.springer.com/article/10.1186/s12944-019-0991-x |
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