Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures
Introduction With pre-diabetes and diabetes increasingly recognized as heterogeneous conditions, assessment of beta-cell function is gaining clinical importance to identify disease subphenotypes. Our study aims to comprehensively validate all types of surrogate indices based on oral glucose toleranc...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-10-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/10/5/e002909.full |
| _version_ | 1798019900202024960 |
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| author | Andreas Fritsche Julia Otten Robert Wagner Martin Heni Andreas Peter Louise Fritsche Andreas L Birkenfeld Katsiaryna Prystupa Rebecka Renklint Youssef Chninou Sebastian Hoerber |
| author_facet | Andreas Fritsche Julia Otten Robert Wagner Martin Heni Andreas Peter Louise Fritsche Andreas L Birkenfeld Katsiaryna Prystupa Rebecka Renklint Youssef Chninou Sebastian Hoerber |
| author_sort | Andreas Fritsche |
| collection | DOAJ |
| description | Introduction With pre-diabetes and diabetes increasingly recognized as heterogeneous conditions, assessment of beta-cell function is gaining clinical importance to identify disease subphenotypes. Our study aims to comprehensively validate all types of surrogate indices based on oral glucose tolerance test (OGTT) and fasting measurements in comparison with gold standard methods.Research design and methods The hyperglycemic clamp extended with glucagon-like peptide 1 (GLP-1) infusion and intravenous glucose tolerance test (IVGTT), as well as OGTT, was performed in two well-phenotyped cohorts. The gold standard–derived indices were compared with surrogate insulin secretion markers, derived from fasting state and OGTT, using both Pearson’s and Spearman’s correlation coefficients. The insulin-based and C-peptide-based indices were analyzed separately in different groups of glucose tolerance and the entire cohorts.Results The highest correlation coefficients were found for area under curve (AUC) (I0-30)/AUC (G0-30), I30/G30, first-phase Stumvoll and Kadowaki model. These indices have high correlation coefficients with measures obtained from both insulin and C-peptide levels from IVGTT and hyperglycemic clamp. AUC (I0-120)/AUC (G0-120), BIGTT-AIR0-60-120, I30/G30, first-phase Stumvoll and AUC (I0-30)/AUC (G0-30) demonstrated the strongest association with incretin-stimulated insulin response.Conclusions We have identified glucose-stimulated and GLP-1-stimulated insulin secretion indices, derived from OGTT and fasting state, that have the strongest correlation with gold standard measures and could be potentially used in future researches and clinical practice. |
| first_indexed | 2024-04-11T16:48:23Z |
| format | Article |
| id | doaj.art-66c89a138dde44fd877680d9f1d293c6 |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-04-11T16:48:23Z |
| publishDate | 2022-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-66c89a138dde44fd877680d9f1d293c62022-12-22T04:13:30ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972022-10-0110510.1136/bmjdrc-2022-002909Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measuresAndreas Fritsche0Julia Otten1Robert Wagner2Martin Heni3Andreas Peter4Louise Fritsche5Andreas L Birkenfeld6Katsiaryna Prystupa7Rebecka Renklint8Youssef Chninou9Sebastian Hoerber10Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, GermanyDepartment of Public Health and Clinical Medicine, Umea University, Umea, SwedenDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, GermanyDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, GermanyGerman Center for Diabetes Research (DZD), Neuherberg, GermanyGerman Center for Diabetes Research (DZD), Neuherberg, GermanyDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, GermanyDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls Universität Tübingen, Tubingen, GermanyDepartment of Public Health and Clinical Medicine, Umea University, Umea, SwedenDepartment of Public Health and Clinical Medicine, Umea University, Umea, SwedenGerman Center for Diabetes Research (DZD), Neuherberg, GermanyIntroduction With pre-diabetes and diabetes increasingly recognized as heterogeneous conditions, assessment of beta-cell function is gaining clinical importance to identify disease subphenotypes. Our study aims to comprehensively validate all types of surrogate indices based on oral glucose tolerance test (OGTT) and fasting measurements in comparison with gold standard methods.Research design and methods The hyperglycemic clamp extended with glucagon-like peptide 1 (GLP-1) infusion and intravenous glucose tolerance test (IVGTT), as well as OGTT, was performed in two well-phenotyped cohorts. The gold standard–derived indices were compared with surrogate insulin secretion markers, derived from fasting state and OGTT, using both Pearson’s and Spearman’s correlation coefficients. The insulin-based and C-peptide-based indices were analyzed separately in different groups of glucose tolerance and the entire cohorts.Results The highest correlation coefficients were found for area under curve (AUC) (I0-30)/AUC (G0-30), I30/G30, first-phase Stumvoll and Kadowaki model. These indices have high correlation coefficients with measures obtained from both insulin and C-peptide levels from IVGTT and hyperglycemic clamp. AUC (I0-120)/AUC (G0-120), BIGTT-AIR0-60-120, I30/G30, first-phase Stumvoll and AUC (I0-30)/AUC (G0-30) demonstrated the strongest association with incretin-stimulated insulin response.Conclusions We have identified glucose-stimulated and GLP-1-stimulated insulin secretion indices, derived from OGTT and fasting state, that have the strongest correlation with gold standard measures and could be potentially used in future researches and clinical practice.https://drc.bmj.com/content/10/5/e002909.full |
| spellingShingle | Andreas Fritsche Julia Otten Robert Wagner Martin Heni Andreas Peter Louise Fritsche Andreas L Birkenfeld Katsiaryna Prystupa Rebecka Renklint Youssef Chninou Sebastian Hoerber Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures BMJ Open Diabetes Research & Care |
| title | Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures |
| title_full | Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures |
| title_fullStr | Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures |
| title_full_unstemmed | Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures |
| title_short | Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures |
| title_sort | comprehensive validation of fasting based and oral glucose tolerance test based indices of insulin secretion against gold standard measures |
| url | https://drc.bmj.com/content/10/5/e002909.full |
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