Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment
Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of regulated cell death resulting from abnormal iron metabolism involving the production of reactive oxygen species. As ferroptosis, autophagy and cancer have been revealed, ferritinophagy has attracted increasing...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1043344/full |
| _version_ | 1811250784487079936 |
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| author | Kai Sun Chenyuan Li Shichong Liao Xinrui Yao Yang Ouyang Yi Liu Zhong Wang Zhiyu Li Feng Yao |
| author_facet | Kai Sun Chenyuan Li Shichong Liao Xinrui Yao Yang Ouyang Yi Liu Zhong Wang Zhiyu Li Feng Yao |
| author_sort | Kai Sun |
| collection | DOAJ |
| description | Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of regulated cell death resulting from abnormal iron metabolism involving the production of reactive oxygen species. As ferroptosis, autophagy and cancer have been revealed, ferritinophagy has attracted increasing attention in cancer development. In this review, we discuss the latest research progress on ferroptosis, autophagy-associated ferroptosis led by ferritinophagy, the regulators of ferritinophagy and promising cancer treatments that target ferritinophagy. Ferritinophagy is at the intersection of ferroptosis and autophagy and plays a significant role in cancer development. The discussed studies provide new insights into the mechanisms of ferritinophagy and promising related treatments for cancer. |
| first_indexed | 2024-04-12T16:09:48Z |
| format | Article |
| id | doaj.art-66cafa04bb7144c3b21c451997f4d001 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T16:09:48Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-66cafa04bb7144c3b21c451997f4d0012022-12-22T03:25:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10433441043344Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatmentKai Sun0Chenyuan Li1Shichong Liao2Xinrui Yao3Yang Ouyang4Yi Liu5Zhong Wang6Zhiyu Li7Feng Yao8Department of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaSchool of Science, University of Sydney, Sydney, New South Wales, NSW, AustraliaDepartment of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery. Renmin Hospital of Wuhan University, Wuhan, ChinaFerritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of regulated cell death resulting from abnormal iron metabolism involving the production of reactive oxygen species. As ferroptosis, autophagy and cancer have been revealed, ferritinophagy has attracted increasing attention in cancer development. In this review, we discuss the latest research progress on ferroptosis, autophagy-associated ferroptosis led by ferritinophagy, the regulators of ferritinophagy and promising cancer treatments that target ferritinophagy. Ferritinophagy is at the intersection of ferroptosis and autophagy and plays a significant role in cancer development. The discussed studies provide new insights into the mechanisms of ferritinophagy and promising related treatments for cancer.https://www.frontiersin.org/articles/10.3389/fphar.2022.1043344/fullferroptosisferritinophagycancerironautophagy |
| spellingShingle | Kai Sun Chenyuan Li Shichong Liao Xinrui Yao Yang Ouyang Yi Liu Zhong Wang Zhiyu Li Feng Yao Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment Frontiers in Pharmacology ferroptosis ferritinophagy cancer iron autophagy |
| title | Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment |
| title_full | Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment |
| title_fullStr | Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment |
| title_full_unstemmed | Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment |
| title_short | Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment |
| title_sort | ferritinophagy a form of autophagic ferroptosis new insights into cancer treatment |
| topic | ferroptosis ferritinophagy cancer iron autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1043344/full |
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