Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review
Abstract Background The aim of this systematic review is to evaluate the changes in gut microbiota (GM) induced by the Ketogenic Diets (KD) as a potential underlying mechanism in the improvement of neurological diseases. Methods A comprehensive search was conducted on three electronic databases, inc...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-023-00893-2 |
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| author | Mahdi Mazandarani Narges Lashkarbolouk Hanieh-Sadat Ejtahed Mostafa Qorbani |
| author_facet | Mahdi Mazandarani Narges Lashkarbolouk Hanieh-Sadat Ejtahed Mostafa Qorbani |
| author_sort | Mahdi Mazandarani |
| collection | DOAJ |
| description | Abstract Background The aim of this systematic review is to evaluate the changes in gut microbiota (GM) induced by the Ketogenic Diets (KD) as a potential underlying mechanism in the improvement of neurological diseases. Methods A comprehensive search was conducted on three electronic databases, including PubMed/Medline, Web of Science, and Scopus until December 2022. The inclusion criteria were studies that described any changes in GM after consuming KD in neurological patients. Full text of studies such as clinical trials and cohorts were added. The quality assessment of cohort studies was conducted using the Newcastle–Ottawa Quality Assessment Scale and for the clinical trials using the Cochrane Collaboration tool. The search, screening, and data extraction were performed by two researchers independently. Results Thirteen studies examining the effects of the KD on the GM in neurological patients were included. Studies have shown that KD improves clinical outcomes by reducing disease severity and recurrence rates. An increase in Proteobacteria phylum, Escherichia, Bacteroides, Prevotella, Faecalibacterium, Lachnospira, Agaricus, and Mrakia genera and a reduction in Firmicutes, and Actinobacteria phyla, Eubacterium, Cronobacter, Saccharomyces, Claviceps, Akkermansia and Dialister genera were reported after KD. Studies showed a reduction in concentrations of fecal short-chain fatty acids and branched-chain fatty acids and an increase in beta Hydroxybutyrate, trimethylamine N-oxide, and N-acetylserotonin levels after KD. Conclusion The KD prescribed in neurological patients has effectively altered the GM composition and GM-derived metabolites. |
| first_indexed | 2024-03-09T15:28:15Z |
| format | Article |
| id | doaj.art-66cbea8fc83040e9be409d10d62289d7 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-03-09T15:28:15Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-66cbea8fc83040e9be409d10d62289d72023-11-26T12:24:40ZengBMCNutrition Journal1475-28912023-11-0122111410.1186/s12937-023-00893-2Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic reviewMahdi Mazandarani0Narges Lashkarbolouk1Hanieh-Sadat Ejtahed2Mostafa Qorbani3Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesObesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Alborz University of Medical SciencesAbstract Background The aim of this systematic review is to evaluate the changes in gut microbiota (GM) induced by the Ketogenic Diets (KD) as a potential underlying mechanism in the improvement of neurological diseases. Methods A comprehensive search was conducted on three electronic databases, including PubMed/Medline, Web of Science, and Scopus until December 2022. The inclusion criteria were studies that described any changes in GM after consuming KD in neurological patients. Full text of studies such as clinical trials and cohorts were added. The quality assessment of cohort studies was conducted using the Newcastle–Ottawa Quality Assessment Scale and for the clinical trials using the Cochrane Collaboration tool. The search, screening, and data extraction were performed by two researchers independently. Results Thirteen studies examining the effects of the KD on the GM in neurological patients were included. Studies have shown that KD improves clinical outcomes by reducing disease severity and recurrence rates. An increase in Proteobacteria phylum, Escherichia, Bacteroides, Prevotella, Faecalibacterium, Lachnospira, Agaricus, and Mrakia genera and a reduction in Firmicutes, and Actinobacteria phyla, Eubacterium, Cronobacter, Saccharomyces, Claviceps, Akkermansia and Dialister genera were reported after KD. Studies showed a reduction in concentrations of fecal short-chain fatty acids and branched-chain fatty acids and an increase in beta Hydroxybutyrate, trimethylamine N-oxide, and N-acetylserotonin levels after KD. Conclusion The KD prescribed in neurological patients has effectively altered the GM composition and GM-derived metabolites.https://doi.org/10.1186/s12937-023-00893-2Ketogenic dietKetonesNeurodegenerative diseasesGut microbiota |
| spellingShingle | Mahdi Mazandarani Narges Lashkarbolouk Hanieh-Sadat Ejtahed Mostafa Qorbani Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review Nutrition Journal Ketogenic diet Ketones Neurodegenerative diseases Gut microbiota |
| title | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
| title_full | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
| title_fullStr | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
| title_full_unstemmed | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
| title_short | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
| title_sort | does the ketogenic diet improve neurological disorders by influencing gut microbiota a systematic review |
| topic | Ketogenic diet Ketones Neurodegenerative diseases Gut microbiota |
| url | https://doi.org/10.1186/s12937-023-00893-2 |
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