The extracellular matrix of the lung and its role in edema formation
The extracellular matrix is composed of a three-dimensional fiber mesh filled with different macromolecules such as: collagen (mainly type I and III), elastin, glycosaminoglycans, and proteoglycans. In the lung, the extracellular matrix has several functions which provide: 1) mechanical tensile and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2007-06-01
|
| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000200010 |
| _version_ | 1818759735908761600 |
|---|---|
| author | Paolo Pelosi Patricia R.M. Rocco Daniela Negrini Alberto Passi |
| author_facet | Paolo Pelosi Patricia R.M. Rocco Daniela Negrini Alberto Passi |
| author_sort | Paolo Pelosi |
| collection | DOAJ |
| description | The extracellular matrix is composed of a three-dimensional fiber mesh filled with different macromolecules such as: collagen (mainly type I and III), elastin, glycosaminoglycans, and proteoglycans. In the lung, the extracellular matrix has several functions which provide: 1) mechanical tensile and compressive strength and elasticity, 2) low mechanical tissue compliance contributing to the maintenance of normal interstitial fluid dynamics, 3) low resistive pathway for an effective gas exchange, d) control of cell behavior by the binding of growth factors, chemokines, cytokines and the interaction with cell-surface receptors, and e) tissue repair and remodeling. Fragmentation and disorganization of extracellular matrix components comprises the protective role of the extracellular matrix, leading to interstitial and eventually severe lung edema. Thus, once conditions of increased microvascular filtration are established, matrix remodeling proceeds fairly rapidly due to the activation of proteases. Conversely, a massive matrix deposition of collagen fiber decreases interstitial compliance and therefore makes the tissue safety factor stronger. As a result, changes in lung extracellular matrix significantly affect edema formation and distribution in the lung.<br>A matriz extracelular é um aglomerado tridimensional demacromoléculas composta por: fibras colágenas (principalmente, tipos I e III), elastina, glicosaminoglicanos e proteoglicanos. No pulmão, a matriz extracelular tem várias funções, tais como: 1) promover estresse tensil e elasticidade tecidual, 2) contribuir para a manutenção da dinâmica de fluidos no interstício, 3) propiciar efetiva troca gasosa, 4) controlar a função celular através de sua ligação com fatores de crescimento, quimiocinas, citocinas e interação com receptores de superfície, e 5) remodelamento e reparo tecidual. A fragmentação e a desorganização da matriz extracelular pode acarretar edema intersticial e, eventualmente, edema alveolar grave. Logo, quando há aumento da filtração microvascular ocorre rápido remodelamento da matriz por ativação de proteases. Destarte, a deposição de fibras colágenas reduz a complacência intersticial limitando o edema. Em conclusão, modificações na matriz extracelular podem afetar a formação e distribuição do edema no pulmão. |
| first_indexed | 2024-12-18T06:47:27Z |
| format | Article |
| id | doaj.art-66d1279f5b224b30b8465546a9c89923 |
| institution | Directory Open Access Journal |
| issn | 0001-3765 1678-2690 |
| language | English |
| last_indexed | 2024-12-18T06:47:27Z |
| publishDate | 2007-06-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-66d1279f5b224b30b8465546a9c899232022-12-21T21:17:27ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências0001-37651678-26902007-06-0179228529710.1590/S0001-37652007000200010The extracellular matrix of the lung and its role in edema formationPaolo PelosiPatricia R.M. RoccoDaniela NegriniAlberto PassiThe extracellular matrix is composed of a three-dimensional fiber mesh filled with different macromolecules such as: collagen (mainly type I and III), elastin, glycosaminoglycans, and proteoglycans. In the lung, the extracellular matrix has several functions which provide: 1) mechanical tensile and compressive strength and elasticity, 2) low mechanical tissue compliance contributing to the maintenance of normal interstitial fluid dynamics, 3) low resistive pathway for an effective gas exchange, d) control of cell behavior by the binding of growth factors, chemokines, cytokines and the interaction with cell-surface receptors, and e) tissue repair and remodeling. Fragmentation and disorganization of extracellular matrix components comprises the protective role of the extracellular matrix, leading to interstitial and eventually severe lung edema. Thus, once conditions of increased microvascular filtration are established, matrix remodeling proceeds fairly rapidly due to the activation of proteases. Conversely, a massive matrix deposition of collagen fiber decreases interstitial compliance and therefore makes the tissue safety factor stronger. As a result, changes in lung extracellular matrix significantly affect edema formation and distribution in the lung.<br>A matriz extracelular é um aglomerado tridimensional demacromoléculas composta por: fibras colágenas (principalmente, tipos I e III), elastina, glicosaminoglicanos e proteoglicanos. No pulmão, a matriz extracelular tem várias funções, tais como: 1) promover estresse tensil e elasticidade tecidual, 2) contribuir para a manutenção da dinâmica de fluidos no interstício, 3) propiciar efetiva troca gasosa, 4) controlar a função celular através de sua ligação com fatores de crescimento, quimiocinas, citocinas e interação com receptores de superfície, e 5) remodelamento e reparo tecidual. A fragmentação e a desorganização da matriz extracelular pode acarretar edema intersticial e, eventualmente, edema alveolar grave. Logo, quando há aumento da filtração microvascular ocorre rápido remodelamento da matriz por ativação de proteases. Destarte, a deposição de fibras colágenas reduz a complacência intersticial limitando o edema. Em conclusão, modificações na matriz extracelular podem afetar a formação e distribuição do edema no pulmão.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000200010colágenoglicosaminoglicanosproteoglicanospressão intersticialcollagenglycosaminoglycansproteoglycaninterstitial pressure |
| spellingShingle | Paolo Pelosi Patricia R.M. Rocco Daniela Negrini Alberto Passi The extracellular matrix of the lung and its role in edema formation Anais da Academia Brasileira de Ciências colágeno glicosaminoglicanos proteoglicanos pressão intersticial collagen glycosaminoglycans proteoglycan interstitial pressure |
| title | The extracellular matrix of the lung and its role in edema formation |
| title_full | The extracellular matrix of the lung and its role in edema formation |
| title_fullStr | The extracellular matrix of the lung and its role in edema formation |
| title_full_unstemmed | The extracellular matrix of the lung and its role in edema formation |
| title_short | The extracellular matrix of the lung and its role in edema formation |
| title_sort | extracellular matrix of the lung and its role in edema formation |
| topic | colágeno glicosaminoglicanos proteoglicanos pressão intersticial collagen glycosaminoglycans proteoglycan interstitial pressure |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000200010 |
| work_keys_str_mv | AT paolopelosi theextracellularmatrixofthelunganditsroleinedemaformation AT patriciarmrocco theextracellularmatrixofthelunganditsroleinedemaformation AT danielanegrini theextracellularmatrixofthelunganditsroleinedemaformation AT albertopassi theextracellularmatrixofthelunganditsroleinedemaformation AT paolopelosi extracellularmatrixofthelunganditsroleinedemaformation AT patriciarmrocco extracellularmatrixofthelunganditsroleinedemaformation AT danielanegrini extracellularmatrixofthelunganditsroleinedemaformation AT albertopassi extracellularmatrixofthelunganditsroleinedemaformation |