Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients
Background and methods Stroke has become a major public health problem worldwide. In this article, we carried out statistical analysis, correlation analysis and principal component analysis (PCA) to evaluate the clinical value of routine hematological indicators in early diagnosis of ischemic stroke...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2020-02-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/8545.pdf |
| _version_ | 1797418732020039680 |
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| author | Xiaofang Cui Wei Wei Xiao Qin Fei Hou Jin Zhu Weiyang Li |
| author_facet | Xiaofang Cui Wei Wei Xiao Qin Fei Hou Jin Zhu Weiyang Li |
| author_sort | Xiaofang Cui |
| collection | DOAJ |
| description | Background and methods Stroke has become a major public health problem worldwide. In this article, we carried out statistical analysis, correlation analysis and principal component analysis (PCA) to evaluate the clinical value of routine hematological indicators in early diagnosis of ischemic stroke using R language. Results For the full blood count comparisons, stroke patients had obvious differences in the distribution width of red blood cells (RDW-CV), average distribution width of red blood cells (RDW-SD), mean hemoglobin concentrations, platelet large cell ratio, mean platelet volume and lymphocytes. Patients with ischemic stroke also exhibited different degrees of abnormalities in liver function test. With respect to renal function, stroke patients had obvious changes in uric acid and urea levels. Finally, when comparing the lipid profile, triglyceride concentrations were increased and high-density lipoprotein cholesterol concentrations were reduced in stroke patients. In addition, correlation analysis among these clinical indicators indicated that there were both common characteristics and differences between patients and health controls. Furthermore, the results of PCA indicated that these clinical indicators could distinguish patients from the healthy controls. Conclusion Conventional hematological clinical indicators, such as liver function, renal function, full blood count and lipid concentration profiles highly correlated with the occurrence of ischemic stroke. Therefore, the detection and analyzation of these clinical indicators are of great significance for the prediction of ischemic stroke. |
| first_indexed | 2024-03-09T06:38:10Z |
| format | Article |
| id | doaj.art-66d286fb214743bcb20393ce3b98e6d2 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:38:10Z |
| publishDate | 2020-02-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-66d286fb214743bcb20393ce3b98e6d22023-12-03T10:55:22ZengPeerJ Inc.PeerJ2167-83592020-02-018e854510.7717/peerj.8545Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patientsXiaofang Cui0Wei Wei1Xiao Qin2Fei Hou3Jin Zhu4Weiyang Li5Jining Medical University, Jining, Shandong, ChinaJining Medical University, Jining, Shandong, ChinaJining Medical University, Jining, Shandong, ChinaJining Medical University, Jining, Shandong, ChinaJining Medical University, Jining, Shandong, ChinaJining Medical University, Jining, Shandong, ChinaBackground and methods Stroke has become a major public health problem worldwide. In this article, we carried out statistical analysis, correlation analysis and principal component analysis (PCA) to evaluate the clinical value of routine hematological indicators in early diagnosis of ischemic stroke using R language. Results For the full blood count comparisons, stroke patients had obvious differences in the distribution width of red blood cells (RDW-CV), average distribution width of red blood cells (RDW-SD), mean hemoglobin concentrations, platelet large cell ratio, mean platelet volume and lymphocytes. Patients with ischemic stroke also exhibited different degrees of abnormalities in liver function test. With respect to renal function, stroke patients had obvious changes in uric acid and urea levels. Finally, when comparing the lipid profile, triglyceride concentrations were increased and high-density lipoprotein cholesterol concentrations were reduced in stroke patients. In addition, correlation analysis among these clinical indicators indicated that there were both common characteristics and differences between patients and health controls. Furthermore, the results of PCA indicated that these clinical indicators could distinguish patients from the healthy controls. Conclusion Conventional hematological clinical indicators, such as liver function, renal function, full blood count and lipid concentration profiles highly correlated with the occurrence of ischemic stroke. Therefore, the detection and analyzation of these clinical indicators are of great significance for the prediction of ischemic stroke.https://peerj.com/articles/8545.pdfStrokeIschemic strokeClinical indicators |
| spellingShingle | Xiaofang Cui Wei Wei Xiao Qin Fei Hou Jin Zhu Weiyang Li Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients PeerJ Stroke Ischemic stroke Clinical indicators |
| title | Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients |
| title_full | Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients |
| title_fullStr | Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients |
| title_full_unstemmed | Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients |
| title_short | Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients |
| title_sort | comparison of routine hematological indicators of liver and kidney function blood count and lipid profile in healthy people and stroke patients |
| topic | Stroke Ischemic stroke Clinical indicators |
| url | https://peerj.com/articles/8545.pdf |
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