Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
Abstract Renal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, par...
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Nature Portfolio
2017-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-05210-6 |
| _version_ | 1818428194127085568 |
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| author | Xia Tan Guochun Chen Yu Liu Letian Zhou Liyu He Di Liu Yexin Liu Fan Zhang Huiqiong Li Hong Liu |
| author_facet | Xia Tan Guochun Chen Yu Liu Letian Zhou Liyu He Di Liu Yexin Liu Fan Zhang Huiqiong Li Hong Liu |
| author_sort | Xia Tan |
| collection | DOAJ |
| description | Abstract Renal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, particularly in those with severe hypoalbuminemia. This study was designed to investigate the application of serum D-dimer as a predictor for thrombotic events after renal biopsy. 400 consecutive native renal biopsies were prospectively included in this 2-month follow-up study. The overall incidence of bleeding and thrombotic complication is 4%, including hematuria or large perinephric hematoma (2.5%, n = 10) and thrombotic complication (1.5%, n = 6). Compared to low serum D-dimer (<2.00 μg/ml), subjects in the group of high serum D-dimer (≥2.00 μg/ml) were more incline to develop thrombotic complications (9.1% versus 0.3%; RR, 30.33; p < 0.001). D-dimer correlated positively with age (rs = 0.258, P < 0.001). Inverse correlations were found for albumin (rs = −0.339, P < 0.001). Taken together, patients with high serum D-dimer carry an increased risk of thrombotic complications after renal biopsy. Our findings suggest that serum D-dimer can serve as a potential predictor for thrombotic events in patients with kidney disease. Further cautions should be given to these subjects. |
| first_indexed | 2024-12-14T14:57:44Z |
| format | Article |
| id | doaj.art-66d44f9f5c524ca2b68ddce04148b6ee |
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| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T14:57:44Z |
| publishDate | 2017-07-01 |
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| spelling | doaj.art-66d44f9f5c524ca2b68ddce04148b6ee2022-12-21T22:56:57ZengNature PortfolioScientific Reports2045-23222017-07-01711710.1038/s41598-017-05210-6Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsyXia Tan0Guochun Chen1Yu Liu2Letian Zhou3Liyu He4Di Liu5Yexin Liu6Fan Zhang7Huiqiong Li8Hong Liu9Department of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanDepartment of Nephrology, The Second Xiangya Hospital of Central South University. Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanAbstract Renal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, particularly in those with severe hypoalbuminemia. This study was designed to investigate the application of serum D-dimer as a predictor for thrombotic events after renal biopsy. 400 consecutive native renal biopsies were prospectively included in this 2-month follow-up study. The overall incidence of bleeding and thrombotic complication is 4%, including hematuria or large perinephric hematoma (2.5%, n = 10) and thrombotic complication (1.5%, n = 6). Compared to low serum D-dimer (<2.00 μg/ml), subjects in the group of high serum D-dimer (≥2.00 μg/ml) were more incline to develop thrombotic complications (9.1% versus 0.3%; RR, 30.33; p < 0.001). D-dimer correlated positively with age (rs = 0.258, P < 0.001). Inverse correlations were found for albumin (rs = −0.339, P < 0.001). Taken together, patients with high serum D-dimer carry an increased risk of thrombotic complications after renal biopsy. Our findings suggest that serum D-dimer can serve as a potential predictor for thrombotic events in patients with kidney disease. Further cautions should be given to these subjects.https://doi.org/10.1038/s41598-017-05210-6 |
| spellingShingle | Xia Tan Guochun Chen Yu Liu Letian Zhou Liyu He Di Liu Yexin Liu Fan Zhang Huiqiong Li Hong Liu Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy Scientific Reports |
| title | Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy |
| title_full | Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy |
| title_fullStr | Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy |
| title_full_unstemmed | Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy |
| title_short | Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy |
| title_sort | serum d dimer is a potential predictor for thromboembolism complications in patients with renal biopsy |
| url | https://doi.org/10.1038/s41598-017-05210-6 |
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