Clinical relevance of the discrepancy in phenylalanine concentrations analyzed using tandem mass spectrometry compared with ion-exchange chromatography in phenylketonuria

Clinical relevance of the discrepancy in phenylalanine concentrations analyzed using tandem mass spectrometry compared with ion-exchange chromatography in phenylketonuria

Introduction: Metabolic control of phenylketonuria (PKU) and compliance with the low-phenylalanine (phe) diet are frequently assessed by measuring blood phe concentrations in dried blood spots (DBS) collected by patients instead of plasma phe concentrations. Objective: Our objective was to investiga...

Full description

Bibliographic Details
Main Authors: Bridget M. Stroup, Patrice K. Held, Phillip Williams, Murray K. Clayton, Sangita G. Murali, Gregory M. Rice, Denise M. Ney
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Bland–Altman
Amino acid analyzer
Phenylalanine analytical methods
Newborn screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426916300015

Similar Items

Similar Items